{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:10:02Z","timestamp":1762297802581},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,2]]},"abstract":"Summary<\/jats:title>Background\/Purpose<\/jats:title>This study determined the threshold doses for \u2018solar erythema\u2019 and for phototoxic responses to 8\u2010methoxypsoralen (8\u2010MOP<\/jats:styled-content>) in white skin H<\/jats:styled-content>anford and grey skin Y<\/jats:styled-content>ucatan miniature swine.<\/jats:p><\/jats:sec>Methods<\/jats:title>For threshold erythema determinations, the UVR<\/jats:styled-content> exposures included both UVA<\/jats:styled-content> (315\u2013400\u2009nm) and UVB<\/jats:styled-content> (290\u2013315\u2009nm) radiation by positioning one fluorescent \u2018sunlamp\u2019 among 10 \u2018PUVA<\/jats:styled-content>\u2019 lamps. With this configuration the UVR<\/jats:styled-content> exposures ranged from 0.5\u20132.8 times the \u2018instrumental MED<\/jats:styled-content>\u2019 (MEDi<\/jats:styled-content>) for H<\/jats:styled-content>anford and from 1.0\u20135.6 times the MEDi<\/jats:styled-content> for Y<\/jats:styled-content>ucatan. For phototoxicity determinations (i.e., with and without topically\u2010applied graduated concentrations of 8\u2010MOP<\/jats:styled-content>), the UVB<\/jats:styled-content> component was minimized by extinguishing the sunlamp, thus permitting higher UVA exposures.<\/jats:p><\/jats:sec>Results<\/jats:title>The Hanford had the lower UV<\/jats:styled-content> erythema dose threshold (1.0\u20131.4 times the MEDi<\/jats:styled-content>) and the erythema that developed was readily observable. The exposure doses for the phototoxicity test were 5\u2009J<\/jats:styled-content>\/cm2<\/jats:sup> of UVA<\/jats:styled-content> in 35 minutes or 10\u2009J<\/jats:styled-content>\/cm2<\/jats:sup> in 70 minutes. The phototoxic (vascular) response to 8\u2010MOP<\/jats:styled-content> was observed in the two highest concentrations (0.01% and 0.1%) in H<\/jats:styled-content>anford pigs, in a dose\u2010related manner. Microscopic evidence of a dose\u2010related response was also observed as the concentration of 8\u2010MOP<\/jats:styled-content> increased.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This verified that the H<\/jats:styled-content>anford miniature swine is the preferable strain for phototoxic effects. In contrast, UVR<\/jats:styled-content> exposure of the Y<\/jats:styled-content>ucatan pig skin produced tanning rather than erythema, confirming that the Y<\/jats:styled-content>ucatan is the more appropriate strain for studying the melanization response. Thus, H<\/jats:styled-content>anford and Y<\/jats:styled-content>ucatan miniature swine have cutaneous photobiological responses that reflect their respective strain differences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2011.00633.x","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T01:07:06Z","timestamp":1325120826000},"page":"34-41","source":"Crossref","is-referenced-by-count":3,"title":["Miniature swine model of phototoxicity testing"],"prefix":"10.1111","volume":"28","author":[{"given":"Heinz","family":"Leigh","sequence":"first","affiliation":[{"name":"Sinclair Research Center LLC Auxvasse MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Donald","family":"Forbes","sequence":"additional","affiliation":[{"name":"Aclairo PDG, Inc. 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