{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:53:38Z","timestamp":1775786018821,"version":"3.50.1"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,2]]},"abstract":"Summary<\/jats:title>Photodynamic therapy (PDT<\/jats:styled-content>) using 5\u2010aminolevulinic acid (5\u2010ALA<\/jats:styled-content>) is an effective treatment for several conditions such as B<\/jats:styled-content>owen's disease, subsets of basal cell carcinomas and actinic keratosis. Surgical resection is the first\u2010choice therapy for extramammary P<\/jats:styled-content>aget's disease (EMPD<\/jats:styled-content>), but extensive resection is highly invasive and recurrences are frequent. We report two cases of genital EMPD<\/jats:styled-content> treated by PDT<\/jats:styled-content> with partial efficacy. The first patient, a 78\u2010year\u2010old male, suffered from pubic and scrotal P<\/jats:styled-content>aget's disease for 6 years despite numerous treatments. The second patient, a 78\u2010year\u2010old female, had vulvar involvement for 2 years that was resistant to multiple treatments. The disease was recurrent and chronic with important pruritus and significant impact on the quality of life. Methyl 5\u2010aminolevulinate was applied for 3\u2009h, and irradiation was applied with red light (630\u2009nm) using a total light dose of 37\u2009J\/cm2<\/jats:sup><\/jats:styled-content> for a period of 10\u2009min. The patients were treated every 2 to 4 weeks for a total of at least three treatments. Both patients experienced a partial transient reduction in their symptoms. One patient had a partial transient remission (<\u200950% reduction of the involved surface), whereas in the other patient, PDT<\/jats:styled-content> failed to reduce the surface area of the lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2011.00635.x","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T01:07:06Z","timestamp":1325120826000},"page":"53-55","source":"Crossref","is-referenced-by-count":17,"title":["Incomplete efficacy of 5\u2010aminolevulinic acid (5 ALA<\/scp>) photodynamic therapy in the treatment of widespread extramammary P<\/scp>aget's disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Abdullah","family":"Al Yousef","sequence":"first","affiliation":[{"name":"Department of General Dermatology and Cutaneous Oncology Ambroise Par\u00e9 University Hospital, University of Versailles\u2010St Quentin Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Boccara","sequence":"additional","affiliation":[{"name":"Department of General Dermatology and Cutaneous Oncology Ambroise Par\u00e9 University Hospital, University of Versailles\u2010St Quentin Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micheline","family":"Moyal\u2010Barracco","sequence":"additional","affiliation":[{"name":"Dermatology Department Tarnier\u2010Cochin University Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Anatomopathology Ambroise Par\u00e9 University Hospital, University of Versailles\u2010St Quentin Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Saiag","sequence":"additional","affiliation":[{"name":"Department of General Dermatology and Cutaneous Oncology Ambroise Par\u00e9 University Hospital, University of Versailles\u2010St Quentin Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(93)90101-H"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04801.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.04.009"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01093.x"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2011.00635.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2011.00635.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:51:04Z","timestamp":1700563864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2011.00635.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1600-0781.2011.00635.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2011.00635.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}