{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:07:24Z","timestamp":1787616444927,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:00:00Z","timestamp":1335916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the clinical efficacy and safety of combining flumetasone ointment with 308\u2010nm excimer laser therapy vs. 308\u2010nm excimer laser monotherapy for the treatment of psoriasis vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty patients with psoriasis vulgaris were recruited; 20 were treated with flumetasone ointment plus 308\u2010nm excimer laser therapy, and the other 20 received only excimer laser monotherapy. The flumetasone ointment was applied topically twice a day, and laser treatments were scheduled twice weekly for a total of 10 treatments. Clinical efficacy was evaluated in a blinded manner by two independent physicians using photographs taken before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 40 patients who received and completed the entire course of therapy, the psoriasis area and severity index score was improved by 82.51\u2009\u00b1\u200911.24% and 72.01\u2009\u00b1\u200920.94% in the combination group and laser group, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&gt;\u20090.05), and the average cumulative dose was 5.06\u2009\u00b1\u20092.20\u2009j\/cm<jats:sup>2<\/jats:sup> in the combination group and 7.75\u2009\u00b1\u20092.25\u2009j\/cm<jats:sup>2<\/jats:sup> in the laser\u2010only group, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical data suggest that combination treatment using flumetasone ointment and a 308\u2010nm excimer laser is superior to laser monotherapy for treatment of psoriasis vulgaris. The combination therapy can increase effectiveness and decrease the total laser dose, thus potentially reducing side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2012.00654.x","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T05:49:12Z","timestamp":1335937752000},"page":"133-136","source":"Crossref","is-referenced-by-count":13,"title":["Clinical efficacy of flumetasone\/salicylic acid ointment combined with 308\u2010nm excimer laser for treatment of psoriasis vulgaris"],"prefix":"10.1111","volume":"28","author":[{"given":"Jie","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Chaoyang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2007.00317.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00509.x"},{"key":"e_1_2_6_4_1","first-page":"555","article-title":"Therapeutic activity of a new combined topical drug (flumethasone pivalate, mineral tar, salicylic acid)","volume":"42","author":"Buzzoni A","year":"1967","journal-title":"Minerva Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120454"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05709.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417384"},{"key":"e_1_2_6_8_1","first-page":"25","article-title":"Effect of combination ointment of flumetason\u2010pivalat 0,02 per cent and salicylic acid (Locasalen) on dermatoses","volume":"48","author":"Lundell E","year":"1973","journal-title":"Z Haut Geschlechtskr"},{"key":"e_1_2_6_9_1","first-page":"791","article-title":"Experience in the treatment of various forms of eczema with fluocinonide ointment (a doubleblind study and its statistical analysis)","volume":"63","author":"Weitgasser H","year":"1974","journal-title":"Schweiz Rundsch Med Prax"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1001\/archderm.1991.01680100108015","article-title":"Are topical corticosteroids useful adjunctive therapy for the treatment of psoriasis with ultraviolet radiation? A review of the literature","volume":"127","author":"Meola T","year":"1991","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_11_1","first-page":"363","article-title":"Evaluation of the effect of local corticosteroids in the phototherapy of psoriasis","volume":"45","author":"Pasi\u0107 A","year":"1991","journal-title":"Acta Med Croatica"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00654.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2012.00654.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T12:28:00Z","timestamp":1697286480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2012.00654.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,2]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1600-0781.2012.00654.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2012.00654.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,2]]}}}