{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:47:47Z","timestamp":1778010467919,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Rodzik fund"},{"name":"the Shahani Fund"},{"name":"the C.S. Livingood Lectureship and Educational Fund of the Department of Dermatology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tristimulus colorimetry and diffuse reflectance spectroscopy (<jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content>) are white\u2010light skin reflectance techniques used to measure the intensity of skin pigmentation. The tristimulus colorimeter is an instrument that measures a perceived color and the <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content> instrument measures biological chromophores of the skin, including oxy\u2010 and deoxyhemoglobin, melanin and scattering. Data gathered from these tools can be used to understand morphological changes induced in skin chromophores due to conditions of the skin or their treatments. The purpose of this study was to evaluate the use of these two instruments in color measurements of acanthosis nigricans (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) lesions. Eight patients with hyperinsulinemia and clinically diagnosable <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> were seen monthly. Skin pigmentation was measured at three sites: the inner forearm, the medial aspect of the posterior neck, and anterior neck unaffected by <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>. Of the three, measured tristimulus <jats:styled-content style=\"fixed-case\"><jats:italic>L<\/jats:italic>*<jats:italic>a<\/jats:italic>*<jats:italic>b<\/jats:italic>*<\/jats:styled-content> color parameters, the luminosity parameter <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content><\/jats:italic>* was found to most reliably distinguish lesion from normally pigmented skin. The <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content> instrument was able to characterize a lesion on the basis of the calculated melanin concentration, though melanin is a weak indicator of skin change and not a reliable measure to be used independently. Calculated oxyhemoglobin and deoxyhemoglobin concentrations were not found to be reliable indicators of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>. Tristimulus colorimetry may provide reliable methods for respectively quantifying and characterizing the objective color change in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, while <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content> may be useful in characterizing changes in skin melanin content associated with this skin condition.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2012.00663.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T09:31:07Z","timestamp":1444728667000},"page":"213-215","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative skin color measurements in acanthosis nigricans patients: colorimetry and diffuse reflectance spectroscopy"],"prefix":"10.1111","volume":"28","author":[{"given":"Bensachee","family":"Pattamadilok","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneetha","family":"Devpura","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Wayne State University  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zain U.","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oma N.","family":"Agbai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranita","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Rehse","sequence":"additional","affiliation":[{"name":"Department of Physics University of Windsor  Windsor ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassel H.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratna","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Wayne State University  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iltefat H.","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604012941401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01272.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(95)00069-R"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08642.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.001664"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00663.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00663.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2012.00663.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:01:54Z","timestamp":1700564514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2012.00663.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1600-0781.2012.00663.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2012.00663.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}