{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T02:39:54Z","timestamp":1771987194171,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30901287"],"award-info":[{"award-number":["30901287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The Q<\/jats:styled-content>\u2010switched alexandrite laser used at 752\u2009nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment\u2010laden cells. In addition, the 75\u2010nanosecond pulse duration produced by this laser approximates the thermal relaxation time for melanosomes, thereby confining the energy to the target. Facial and labial dark brown macules quickly identify patients with P<\/jats:styled-content>eutz\u2013J<\/jats:styled-content>eghers syndrome. These lentigines may be cosmetically disfiguring. The Q<\/jats:styled-content>\u2010switched alexandrite laser produces clinically significant fading of mucocutaneous melanosis in association with P<\/jats:styled-content>eutz\u2013J<\/jats:styled-content>eghers syndrome without complications often seen with other therapeutic modalities.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate the efficacy and safety of the Q<\/jats:styled-content>\u2010switched alexandrite laser in treating facial and labial lentigines of P<\/jats:styled-content>eutz\u2013J<\/jats:styled-content>eghers syndrome.<\/jats:p><\/jats:sec>Subjects<\/jats:title>43 patients diagnosed with P<\/jats:styled-content>eutz\u2013J<\/jats:styled-content>eghers syndrome were treated and studied in our laser center from 2000 to 2010.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used a Q<\/jats:styled-content>\u2010switched alexandrite laser specified with 75\u2009ns pulse length, emitting at 752\u2009nm and with a 2.4\u2009mm\u2010diameter spot size. The lesional skin was irradiated with fluences of 5\u20137 J\/cm2<\/jats:styled-content>. The treatment intervals were 3 months.<\/jats:p><\/jats:sec>Results<\/jats:title>After treatment with the Q<\/jats:styled-content>\u2010switched alexandrite laser, 55.8% (24\/43) of the patients had excellent results in which more than 75% of the pigments cleared, and 44.2% (19\/43) showed good results. Three sessions were required to obtain excellent results. We observed no serious complications.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We obtain a successful outcome in the treatment of these lentigines with Q<\/jats:styled-content>\u2010switched alexandrite laser and consider it the treatment of choice for these lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2012.00672.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T09:09:47Z","timestamp":1444727387000},"page":"196-199","source":"Crossref","is-referenced-by-count":23,"title":["Q<\/scp>\u2010switched alexandrite laser treatment of facial and labial lentigines associated with P<\/scp>eutz\u2013J<\/scp>eghers syndrome"],"prefix":"10.1111","volume":"28","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.12.1007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.6.e77"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060035012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198499"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03648.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01868.x"},{"key":"e_1_2_7_8_1","volume-title":"Dermatology","author":"Moschella SL","year":"1985"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70446-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01192.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050070"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00672.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00672.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2012.00672.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:01:29Z","timestamp":1700564489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2012.00672.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1600-0781.2012.00672.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2012.00672.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}