{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:35:13Z","timestamp":1772458513201,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Despite the fact that most people apply less sunscreen than the 2\u2009mg\/cm<jats:sup>2<\/jats:sup> required to measure sun protection factor (<jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>), there is a lack of clinical data on the protection afforded from lower applied quantities. The aim of this study was to compare the ability of sunscreens to protect against <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced polymorphous light eruption (<jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>) when applied at 2\u2009mg\/cm<jats:sup>2<\/jats:sup> and 1\u2009mg\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content> 45 sunscreens (one with a high level and one with a low level of <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> protection) were applied at 2\u2009mg\/cm<jats:sup>2<\/jats:sup> and 1\u2009mg\/cm<jats:sup>2<\/jats:sup> to four randomized 6\u2009\u00d7\u20096\u2009cm areas on the upper thorax of 15 female patients with a typical history of <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>. The areas were exposed daily to increasing <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> radiation until a <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> reaction was detected or a maximum of five consecutive days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of patients who developed a <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> reaction with the high <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010protection sunscreen was significantly lower (0%) than with the low <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010protection sunscreen (73%) when both sunscreens were applied at 2\u2009mg\/cm<jats:sup>2<\/jats:sup> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.004). At 1\u2009mg\/cm<jats:sup>2<\/jats:sup>, 33% and 80% of patients presented a <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> reaction with the high and low <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010protection sunscreen, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.064).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content> and high <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010protection broad spectrum sunscreen was able to protect the majority of patients from the development of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> reaction even at 1\u2009mg\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2012.00678.x","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T01:38:34Z","timestamp":1347500314000},"page":"240-243","source":"Crossref","is-referenced-by-count":14,"title":["Influence of the quantity of sunscreen applied on the ability to protect against ultraviolet\u2010induced polymorphous light eruption"],"prefix":"10.1111","volume":"28","author":[{"given":"Robert","family":"Bissonnette","sequence":"first","affiliation":[{"name":"Innovaderm Research Inc.  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Nigen","sequence":"additional","affiliation":[{"name":"Innovaderm Research Inc.  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Bolduc","sequence":"additional","affiliation":[{"name":"Innovaderm Research Inc.  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Labeling and effectiveness testing; sunscreen drug products for over\u2010the\u2010counter human use. 21 CFR Parts 201 and 310. Sect. 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