{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:36:36Z","timestamp":1790141796596,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Conventional photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) can be inconvenient and uncomfortable. We studied low irradiance <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> using an ambulatory inorganic light\u2010emitting diode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients with 61 lesions [superficial basal cell carcinoma (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200930), Bowen's disease (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200930), and actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>; <jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20091)] were studied. Two treatments of ambulatory <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> were undertaken 1 week apart (one treatment for <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>). Clinical response was determined at 3 months, and the treatment cycle was repeated if there was residual disease. The endpoints assessed were pain during treatment (numerical rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>); 0\u201310) and outcome at 1 year. Twenty\u2010three of these patients also received conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> to separate lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> pain scores during first and second treatment were 2 (range 0\u20139) and 4 (0\u20139), respectively. Lesion clearance rate at 1 year after ambulatory <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was 84% (21\/25 lesions in 22 patients). Of the twenty\u2010three patients treated with both ambulatory and conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, the median <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> was 1 (0\u20137) and 5 (1.5\u20139), respectively, with most patients preferring ambulatory <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ambulatory <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is effective for superficial non\u2010melanoma skin cancer, with 1 year clearance rates comparative to conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Low irradiance ambulatory <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> may be less painful and more convenient than conventional <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2012.00681.x","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T01:38:34Z","timestamp":1347500314000},"page":"235-239","source":"Crossref","is-referenced-by-count":44,"title":["Ambulatory photodynamic therapy using low irradiance inorganic light\u2010emitting diodes for the treatment of non\u2010melanoma skin cancer: an open study"],"prefix":"10.1111","volume":"28","author":[{"given":"Sally Helen","family":"Ibbotson","sequence":"first","affiliation":[{"name":"Photobiology Unit Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Photobiology Unit Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08882.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10429.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.048"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05652.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06991.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5199"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09096.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00116-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08450.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07145.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.060"},{"key":"e_1_2_6_14_1","first-page":"547","article-title":"Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial","volume":"18","author":"Basset\u2010Seguin N","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02803.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.729"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106577"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2012.00681.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2012.00681.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:10:46Z","timestamp":1700565046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2012.00681.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1600-0781.2012.00681.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2012.00681.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]}}}