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The present investigation was designed to determine the protective effects of MT\u2010Se against Bacillus Calmette\u2013Gu\u00e9rin (BCG)\/lipopolysaccharide (LPS)\u2010induced hepatic injury in mice. In BCG\/LPS\u2010induced hepatic injury model, MT\u2010Se administered (i.g.) at doses of 5, 10, or 20\u2003mg\/kg to BCG\/LPS\u2010treated mice for 10\u2003days, significantly reduced the increase in plasma aminotransferase, reduced the severe extent of hepatic cell damage and the immigration of inflammatory cells. The MT\u2010Se particles also attenuated the increase in the content of thiobarbituric acid\u2010reactive substances and enhanced the decrease in reduced activities of superoxide dismutase and glutathione peroxidase (GPx). However, treatment with MT\u2010Se suppressed the increase in nitric oxide levels both in plasma and liver tissue. Furthermore, supplementation with MT\u2010Se at the dose of 10\u2003mg\/kg (composed of 9.9\u2003mg\/kg melatonin and 0.1\u2003mg\/kg selenium) had great capability to protect against hepatocellular damage than a similar dose of melatonin (10\u2003mg\/kg) or selenium (0.1\u2003mg\/kg) alone. This effect may relate to its higher antioxidant efficacy in decreasing lipid peroxidation and increasing GPx activity. These results suggest that the mode of MT\u2010Se hepatic protective action is, at least in part, related to its antioxidant properties.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2005.00231.x","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T16:32:29Z","timestamp":1285259549000},"page":"156-163","source":"Crossref","is-referenced-by-count":77,"title":["Melatonin\u2010selenium nanoparticles inhibit oxidative stress and protect against hepatic injury induced by Bacillus Calmette\u2013Gu\u00e9rin\/lipopolysaccharide in 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