{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:30:41Z","timestamp":1783128641612,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T00:00:00Z","timestamp":1137974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The effect of dim (5, 10 and 50\u20031x) light at night on night plasma melatonin level (NML) and night plasma insulin\u2010like growth factor\u20101 (IGF\u20101) level was determined in 12 prepubertal Holstein heifers (245\u2003\u00b1\u200316\u2003days age) using a 4\u2003\u00d7\u20034 Latin Square design with 14\u2010day treatment and 14\u2010day recovery periods. Blood samples were collected at 23:00\u2003hr (prior to the 8\u2003hr night treatment which commenced at mid\u2010night) on days 0, 3 and 13, and throughout the night at 01:00, 02:00, 03:00, 04:00, 06:00 and 08:00\u2003hr on days 1, 4 and 14 of treatment. Plasma was analysed by radioimmunoassay for melatonin (all samples) and IGF\u20101 (samples for day 14, 04:00\u2003hr only). Treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) and treatment\u2003\u00d7\u2003time (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) were significant for NML. Exposure to 50\u2003lx suppressed NML by 50% during the initial 2\u2003hr of the night, but not thereafter. Exposure to 5 and 10\u2003lx had no effect on NML. The NML response to 50\u2003lx was found on all treatment days studied (treatment\u2003\u00d7\u2003time\u2003\u00d7\u2003day; <jats:italic>P<\/jats:italic>\u2003=\u20030.99). There was no treatment effect on plasma IGF\u20101 level (<jats:italic>P<\/jats:italic>\u2003=\u20030.89), but plasma IGF\u20101 level was higher (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) during period 4. Plasma IGF\u20101 level and NML tended (<jats:italic>P<\/jats:italic>\u2003=\u20030.10) to be negatively correlated. Light intensities of 10\u2003lx or less appear safe for use at night in dairy barns where darkness is recommended.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2005.00303.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T09:22:02Z","timestamp":1138008122000},"page":"225-229","source":"Crossref","is-referenced-by-count":25,"title":["Plasma melatonin and insulin\u2010like growth factor\u20101 responses to dim light at night in dairy heifers"],"prefix":"10.1111","volume":"40","author":[{"given":"P.","family":"Muthuramalingam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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