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The rats were decapitated on 5th (short\u2010term group) or 50th day (long\u2010term group) after CP injection. Traits of reproductive organs, sperm characteristics, testicular histological findings, and the lipid peroxidation in the testicular tissue were determined. Melatonin mitigated CP\u2010induced reductions in testes, epididymis and accessory gland weights in rats decapitated on day 5. Both short\u2010 and long\u2010term CP treatment decreased sperm concentration, sperm motility and increased abnormal sperm rates compared with the control. But the reduction of sperm concentration in long\u2010term CP treatment was insignificant. Although treatment with melatonin provided moderately normalization with respect to sperm concentration in short\u2010term treatment group, melatonin caused a marked normalization of sperm motility in both CP\u2003+\u2003melatonin groups. Both groups treated with the melatonin showed decreases in abnormal sperm rates compared with alone CP. While testicular malondialdehyde levels were elevated after CP treatment, glutathione peroxidase activity decreased significantly in both groups. Glutathione levels reduced after long\u2010term treatment, but not in short\u2010term group by CP administration. Treatment with CP plus melatonin provided significant amelioration of oxidative stress parameters. Histopathological findings of testes in both short\u2010 and long\u2010term treatment groups paralleled the biochemical and spermatogenic results. This study clearly indicates that CP\u2010treatment impaired markedly testicular function and combined treatment with melatonin prevented much of the toxicity in rats.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2006.00327.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T01:30:45Z","timestamp":1145583045000},"page":"21-27","source":"Crossref","is-referenced-by-count":139,"title":["Chemoprotective effect of melatonin against cisplatin\u2010induced testicular toxicity in rats"],"prefix":"10.1111","volume":"41","author":[{"given":"Ahmet","family":"Ate\u015f\u015fahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"\u015eahna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaffari","family":"T\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali 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