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Two groups of SAMP8 mice (males and females) were compared with their respective control groups of SAMR1 mice (senescence\u2010resistant inbred strain) to determine their oxidative status without melatonin treatment. Four other groups of the same characteristics were treated with melatonin (10\u2003mg\/kg\/day) in their drinking water. The melatonin concentration in the feeding bottles was titrated according to water consumption and body weight (i.e. 0.06\u2003mg\/mL for 30\u2003g of body weight and 5\u2003mL\/day of water consumption). The treatment began when animals were 1\u2010month old and continued for 9\u2003months. When mice were 10\u2010month old, they were anesthetized and blood was obtained. Plasma and erythrocytes were processed to examine oxidative stress markers: reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione S\u2010transferase (GST), thiobarbituric acid reactive substances (TBARS), and hemolysis. The results showed greater oxidative stress in SAMP8 than in SAMR1, largely because of a decrease in GSH levels and to an increase in GSSG and TBARS with the subsequent induction of the antioxidant enzymes GPX and GR. Melatonin, as an antioxidant molecule, improved the glutathione\u2010related parameters, prevented the induction of GPX in senescent groups, and promoted a decrease in SOD and TBARS in almost all the groups.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2006.00344.x","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T10:26:51Z","timestamp":1149848811000},"page":"142-149","source":"Crossref","is-referenced-by-count":39,"title":["Melatonin reduces oxidative stress in erythrocytes and plasma of senescence\u2010accelerated mice"],"prefix":"10.1111","volume":"41","author":[{"given":"M. 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