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The aim of the present experiment was to compare the concentration of E2 in the blood plasma and in the cerebrospinal fluid (CSF) from the third ventricle in groups of ovariectomized, estradiol treated ewes maintained under short day (SD) or long day (LD) conditions and to study the involvement of the pineal gland in this photoperiodic regulation. Pinealectomized and sham\u2010operated ewes were equipped with an intracerebral cannula to sample the CSF. The plasma E2 concentrations showed no difference between LD and SD in sham\u2010operated and pinealectomized animals. In contrast, in the CSF, E2 concentration was higher in the LD than the SD group, and pinealectomy suppressed this effect of photoperiod. Concomitantly, the stimulatory effect of SD on luteinizing hormone levels observed in sham\u2010operated ewes was abolished by pinealectomy. The results demonstrate that LD increases the E2 concentration in the CSF by a mechanism involving the pineal gland.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2006.00370.x","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T12:19:17Z","timestamp":1154521157000},"page":"306-312","source":"Crossref","is-referenced-by-count":24,"title":["Concentrations of estradiol in ewe cerebrospinal fluid are modulated by photoperiod through pineal\u2010dependent mechanisms"],"prefix":"10.1111","volume":"41","author":[{"given":"Jean\u2010Claude","family":"Thiery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lomet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Liere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Tricoire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Delagrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Malpaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.8.1045"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(02)00611-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2003.10.009"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.10.023"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02796.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod34.2.265"},{"key":"e_1_2_7_8_2","first-page":"185","article-title":"Neuroendocrine basis of seasonal reproduction","volume":"40","author":"Karsch FJ","year":"1984","journal-title":"Rec Prog Horm Res"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod27.3.580"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0960181"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod52.5.1114"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1350421"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod50.5.1168"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.6.1544"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00726.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0188"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.6.5208"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.1.190"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1286.017"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(02)00148-0"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-92-3-799"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-105-2-421"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0620141"},{"key":"e_1_2_7_24_2","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1210\/endo.136.8.7628356","article-title":"Luteinizing hormone (LH)\u2010releasing hormone in third ventricular cerbrospinal fluid of the ewe: correlation with LH pulses and the LH surge","volume":"136","author":"Skinner DC","year":"1995","journal-title":"Endocrinology"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.1.8585"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00563-0"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1010625"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.10.7074"},{"key":"e_1_2_7_29_2","first-page":"2291","article-title":"Dosage radioimmunologique de l'hormone lut\u00e9inisante plasmatique chez le mouton. 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