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To evaluate the chemopreventive function of melatonin in this experimental model, Wistar male rats received a single i.p. injection of NDEA or vehicle followed by weekly s.c. injections of carbon tetrachloride or vehicle for 6\u2003weeks. Melatonin (5\u2003mg\/kg body weight) or its vehicle (0.5\u2003mL saline) was given i.p. on a daily basis 2\u2003hr before lights off for 20\u2003wk. At the end of this period the rats were killed and liver and blood samples were taken for histological and biochemical studies. As markers for liver function, the activity of aspartate transaminase (AST) and alanine transaminase (ALT) and the levels of \u03b1\u2010fetoprotein were measured in serum. To assess lipid peroxidation and the antioxidant status in liver and blood, the levels of thiobarbituric acid reactive substances (TBARS) and of reduced glutathione (GSH) were measured. The activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S\u2010transferase (GST) was assessed in liver and erythrocyte fraction of NDEA\u2010treated rats. NDEA administration inhibited body weight, macro\u2010 and microscopically detectable liver tumors and increased levels of plasma AST, ALT and \u03b1\u2010fetoprotein. NDEA treatment decreased liver TBARS levels and CAT and SOD activities and increased liver GSH levels and GST and GPx activities. Plasma TBARS were augmented, while plasma GSH levels and the activities of erythrocyte CAT, SOD, GST and GPx decreased, in NDEA\u2010treated rats. Melatonin administration significantly curtailed tumor development and counteracted all the biochemical effects.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2007.00478.x","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T10:05:25Z","timestamp":1184839525000},"page":"305-312","source":"Crossref","is-referenced-by-count":49,"title":["Prevention by melatonin of hepatocarcinogenesis in rats injected with <i>N<\/i>\u2010nitrosodiethylamine"],"prefix":"10.1111","volume":"43","author":[{"given":"Perumal","family":"Subramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankaran","family":"Mirunalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadiyala Babu","family":"Dakshayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seithikurippu 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