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However, the detailed effects and mechanisms of this surprisingly pleiotropic indole on the hair follicle (HF) regarding growth control and pigmentation have not yet been completely understood. While unspecific melatonin binding sites have long been identified (e.g., in goat and mouse HFs), specific melatonin membrane MT2 receptor transcripts and both protein and mRNA expression for a specific nuclear melatonin binding site [retinoid\u2010related orphan receptor \u03b1 (ROR\u03b1)] have only recently been identified in murine HFs. MT1, known to be expressed in human skin cells, is not transcribed in mouse skin. After initial enzymologic data from hamster skin related to potential intracutaneous melatonin synthesis, it has recently been demonstrated that murine and human skin, namely human scalp HFs in anagen, are important sites of extrapineal melatonin synthesis. Moreover, HF melatonin production is enhanced by catecholamines (as it classically occurs in the pineal gland). Melatonin may also functionally play a role in hair\u2010cycle control, as it down\u2010regulates both apoptosis and estrogen receptor\u2010\u03b1 expression, and modulates MT2 and ROR\u03b1 expression in murine skin in a hair\u2010cycle\u2010dependent manner. Because of melatonin\u2032s additional potency as a free radical scavenger and DNA repair inducer, the metabolically and proliferatively highly active anagen hair bulb may also exploit melatonin synthesis in loco as a self\u2010cytoprotective strategy.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2007.00512.x","type":"journal-article","created":{"date-parts":[[2007,10,27]],"date-time":"2007-10-27T19:15:48Z","timestamp":1193512548000},"page":"1-15","source":"Crossref","is-referenced-by-count":121,"title":["Melatonin and the hair follicle"],"prefix":"10.1111","volume":"44","author":[{"given":"Tobias W.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Slominski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond 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