{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:26:53Z","timestamp":1790076413176,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We investigated how maternal melatonin is regulated in pregnant rats. To examine the involvement of the conceptus (fetus and placenta) in serum melatonin concentrations, the number of conceptuses was experimentally reduced to one on day 7 of pregnancy (1\u2010conceptus group). Maternal circulating nighttime melatonin levels increased toward day 21 of pregnancy and rapidly decreased to the non\u2010pregnancy levels after parturition, whereas the maternal serum nighttime melatonin levels of the 1\u2010conceptus group on day 21 of pregnancy were significantly lower than normal pregnancy bearing dams more than 10 conceptuses. When the fetuses were removed by fetectomy (all fetuses but not the placentae) on day 12 of pregnancy, serum melatonin concentrations were not decreased. To examine the source of circulating maternal melatonin, mRNA expression of <jats:italic>N<\/jats:italic>\u2010acetyltransferase (NAT), which is a late limiting enzyme for melatonin synthesis, was examined in the placenta and fetal pineal. NAT was not expressed in the placenta and was negligible in the pineal gland of the fetus compared with the mother\u2019s pineal gland. To examine the effect of placental hormones on maternal melatonin production, a conditioned medium, which was made by incubating placenta of day 20 of pregnancy with medium, was injected into the 1\u2010conceptus dams from day 17 to day 20 of pregnancy. Injection of conditioned medium significantly increased serum melatonin concentrations compared with the control values whereas charcoal treatment abolished the stimulatory effect of conditioned medium. In conclusion, maternal circulating melatonin is from the maternal pineal gland and is increased by placental hormones during pregnancy.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2007.00537.x","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T09:28:04Z","timestamp":1205400484000},"page":"335-340","source":"Crossref","is-referenced-by-count":40,"title":["Fetal\/placental regulation of maternal melatonin in rats"],"prefix":"10.1111","volume":"44","author":[{"given":"Hiroshi","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950140307"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00461.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(99)00093-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19990308"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0952-7_1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500482074"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899808999391"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.37"},{"key":"e_1_2_6_10_2","first-page":"29","article-title":"Pattern of melatonin secretion mediates transfer of photoperiod information from mother to fetus in mammals","volume":"192","author":"Goldman BD","year":"2003","journal-title":"Sci STKE"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(73)90416-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9819"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000126132"},{"key":"e_1_2_6_14_2","first-page":"57","article-title":"Melatonin; a potent, endogenous hydroxyl radical scavenger","volume":"1","author":"Tan DX","year":"1993","journal-title":"Endocr J"},{"key":"e_1_2_6_15_2","first-page":"246","article-title":"Melatonin: lowering the high price of free radicals","volume":"15","author":"Reiter RJ","year":"2000","journal-title":"News Physiol Sci"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00376.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00407.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00209.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.300103.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.300104.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90355-4"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1911-9_1"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051012"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00668-4"},{"key":"e_1_2_6_25_2","first-page":"174","article-title":"Effects of sex steroids on pienal enzymes","volume":"78","author":"Daya S","year":"1982","journal-title":"S Afri J Sci"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(95)00172-M"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01670029"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-105-3-846"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-5-1687"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1290405"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1998.tb00551.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.2.398"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199803300-00003"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0021-9258(19)75757-3","article-title":"The primary structure of rat ribosomal protein L19. 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