{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:14Z","timestamp":1787312654914,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    Melatonin, an indolamine produced and secreted predominately by the pineal gland, exhibits a variety of physiological functions, possesses antioxidant and antitumor properties. In this study, we have shown that pharmacologic concentration (1\u2003m\n                    <jats:sc>m<\/jats:sc>\n                    ) of melatonin significantly reduced cell migration and invasion of T98G and U251 glioma cells after 24\u2010hr treatment and inhibited expression of matrix metalloproteinase 2 (MMP 2) and MMP 9. The melatonin inhibition of cell migration and invasion was associated with its reduction of intracellular basal free radical generation. Melatonin at pharmacologic concentration also inhibited the constitutive activation of the reactive oxygen species downstream transcription factor nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells (NF\u2010\u03baB). Furthermore, pyrrolidine dithiocarbamate, a NF\u2010\u03baB\u2010specific inhibitor, at 10\u2003\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    displayed anti\u2010migration and invasion effects and inhibition of MMP 2 and MMP 9 expression resembling that of melatonin. Taken together, it is concluded that inhibition of migration and invasion of glioma cells by melatonin is associated with the latter in its inhibition of oxidative stress pathway. This suggests a potential therapeutic application of melatonin in the treatment of glioma.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-079x.2012.00985.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T12:54:35Z","timestamp":1328792075000},"page":"180-187","source":"Crossref","is-referenced-by-count":61,"title":["Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells"],"prefix":"10.1111","volume":"53","author":[{"given":"Juntao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linli","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng\u2010Ang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000188"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-2-151"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90087-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01109-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00555.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701163360306"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8001-x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.10.007"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2009.11.014"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786848640"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:169"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00937.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00551.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00234.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026023394443"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-079X.2003.00092.x"},{"key":"e_1_2_7_19_2","first-page":"57","article-title":"Melatonin: a potent, endogenous hydroxyl radical scavenger","volume":"1","author":"Tan DX","year":"1993","journal-title":"Endocr J"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2003_3637"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00052-5"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986710794183015"},{"key":"e_1_2_7_23_2","first-page":"4383","article-title":"Influence of melatonin on invasive and metastatic properties of MCF\u20107 human breast cancer cells","volume":"58","author":"Cos S","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00600.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00404.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00408.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2354"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05533.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.062"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0158-0"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01934.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200807195"},{"key":"e_1_2_7_33_2","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski TP","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0418-5"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.01.023"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1181"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00582.x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.015"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1046"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.2165\/11592590-000000000-00000"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20874"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00525.2002"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060651"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.04.015"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000044378.09409.b5"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.02.044"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(98)00037-0"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-579X(02)00128-1"}],"container-title":["Journal of Pineal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-079X.2012.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-079X.2012.00985.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1600-079X.2012.00985.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-079X.2012.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:47:29Z","timestamp":1772977649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-079X.2012.00985.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1600-079X.2012.00985.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-079x.2012.00985.x","archive":["Portico"],"relation":{},"ISSN":["0742-3098","1600-079X"],"issn-type":[{"value":"0742-3098","type":"print"},{"value":"1600-079X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,8]]}}}