{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:14:11Z","timestamp":1792671251278,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The objective of the present study was to investigate the effect of melatonin on the liver inflammatory and regenerative response in an animal model of fulminant hepatic failure (FHF) of viral origin. Rabbits were experimentally infected with 2\u2003\u00d7\u200310<jats:sup>4<\/jats:sup> hemagglutination units of a rabbit hemorrhagic disease virus (RHDV) isolate and received melatonin at two concentrations of 10 or 20\u2003mg\/kg at 0, 12 and 24\u2003hr postinfection. RHDV infection induced an inflammatory response, with increased expression of toll\u2010like receptor 4, high\u2010mobility group box (HMGB)1, interleukin (IL)\u20101\u03b2, IL\u20106, tumor necrosis factor\u2010\u03b1, and C\u2010reactive protein, and decreased expression of decay accelerating factor (DAF\/CD55). These effects were significantly reduced by melatonin. Matrix metalloproteinase\u20109 expression was also lowered in melatonin\u2010treated rabbits. RHDV infection inhibited the hepatic regenerative\/proliferative response, with a reduced expression of hepatocyte growth factor (HGF), epidermal growth factor, platelet\u2010derived growth factor (PDGF)\u2010B and vascular endothelial growth factor and their receptors; these responses were prevented by melatonin administration. Melatonin treatment also resulted in reduced expression of phosphorylated Janus kinase and enhanced expression of extracellular mitogen\u2010activated protein kinase (ERK) and signal transducer and activator of transcription (STAT) 3. Our findings show that anti\u2010inflammatory effects and stimulation of regenerative mechanisms contribute to the beneficial effects of melatonin in rabbits with experimental infection by RHDV and support a potential hepatoprotective role of melatonin in FHF.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2012.00995.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T10:21:46Z","timestamp":1332152506000},"page":"270-278","source":"Crossref","is-referenced-by-count":63,"title":["RETRACTED: Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin"],"prefix":"10.1111","volume":"53","author":[{"given":"Almudena","family":"Laliena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz 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