{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:40:53Z","timestamp":1789342853778,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Melatonin exerts strong anti\u2010tumour activity via several mechanisms, including anti\u2010proliferative and pro\u2010apoptotic effects in addition to its potent antioxidant activity. Several studies have investigated the effects of melatonin on haematological malignancies. However, the previous studies investigating lymphoid malignancies have been largely restricted to a single type of malignancy, Burkitt\u2019s lymphoma (BL). Thus, we examined the actions of melatonin on the growth and apoptosis in a small panel of cell lines representing different human lymphoid malignancies including Ramos (Epstein\u2013Barr virus\u2013negative BL), SU\u2010DHL\u20104 (diffuse large B cell lymphoma), DoHH2 (follicular B non\u2010Hodgkin lymphoma) and JURKAT (acute T cell leukaemia). We showed that melatonin promotes cell cycle arrest and apoptosis in all these cells, although there was marked variations in responses among different cell lines (sensitivity; Ramos\/DoHH2\u2003&gt;\u2003SU\u2010DHL\u20104\u2003&gt;\u2003JURKAT). Melatonin\u2010induced apoptosis was relatively rapid, with increased caspase 3 and PARP cleavage detected within 0.5\u20131\u2003h following melatonin addition. Moreover, there was evidence for rapid processing of both caspase 9, as well as a breakdown of the mitochondrial inner transmembrane potential. On the contrary, caspase activation was detected only in SU\u2010DHL\u20104 and Ramos cells following melatonin treatment suggesting that the extrinsic pathway does not make a consistent contribution to melatonin\u2010induced apoptosis in malignant lymphocytes. Although all cell lines expressed the high\u2010affinity melatonin receptors, MT1 and MT2, melatonin\u2010induced caspase activation appeared to be independent these receptors. Our findings confirm that melatonin could be a potential chemotherapeutic\/preventive agent for malignant lymphocytes. However, it is necessary to take into account that different lymphoid malignancies may differ in their response to melatonin.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2012.01006.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T18:16:35Z","timestamp":1334772995000},"page":"366-373","source":"Crossref","is-referenced-by-count":74,"title":["Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines"],"prefix":"10.1111","volume":"53","author":[{"given":"Marina","family":"S\u00e1nchez\u2010Hidalgo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina A.","family":"de la Lastra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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