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In the recent years, a variety of anti\u2010inflammatory and antioxidant effects have been observed when melatonin is applied exogenously under both in vivo and in vitro conditions. A number of studies suggest that this indole may exert its anti\u2010inflammatory effects through the regulation of different molecular pathways. It has been documented that melatonin inhibits the expression of the isoforms of inducible nitric oxide synthase and cyclooxygenase and limits the production of excessive amounts of nitric oxide, prostanoids, and leukotrienes, as well as other mediators of the inflammatory process such as cytokines, chemokines, and adhesion molecules. Melatonin\u2019s anti\u2010inflammatory effects are related to the modulation of a number of transcription factors such as nuclear factor kappa B, hypoxia\u2010inducible factor, nuclear factor erythroid 2\u2010related factor 2, and others. Melatonin\u2019s effects on the DNA\u2010binding capacity of transcription factors may be regulated through the inhibition of protein kinases involved in signal transduction, such as mitogen\u2010activated protein kinases. This review summarizes recent research data focusing on the modulation of the expression of different inflammatory mediators by melatonin and the effects on cell signaling pathways responsible for the indole\u2019s anti\u2010inflammatory activity. Although there are a numerous published reports that have analyzed melatonin\u2019s anti\u2010inflammatory properties, further studies are necessary to elucidate its complex regulatory mechanisms in different cellular types and tissues.<\/jats:p>","DOI":"10.1111\/j.1600-079x.2012.01014.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T18:33:00Z","timestamp":1338489180000},"page":"1-14","source":"Crossref","is-referenced-by-count":561,"title":["A review of the molecular aspects of melatonin\u2019s anti\u2010inflammatory actions: recent insights and new perspectives"],"prefix":"10.1111","volume":"54","author":[{"given":"Jos\u00e9 L.","family":"Mauriz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar 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