{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:04:44Z","timestamp":1761059084320},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:00:00Z","timestamp":1173052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>Overreaching (OVR) is defined as the initial phase of overtraining syndrome and is known as a metabolic imbalance leading to short\u2010term fatigue. Exercise increases reactive oxygen species production, which can oxidize intracellular structures impairing cell function and thus leads to OVR process. The aim of this work is to study the behavior of oxidative stress markers in subjects submitted to an OVR protocol. Thirty rats were divided in exercise and control group, and submitted to an 8\u2010week\u2010endurance training (ET) and a 3\u2010week\u2010OVR protocol. Thiobarbituric acid reactive substances (TBARs), reactive carbonylated derivatives (RCD), glutathione reductase (GR), catalase (CAT) and citrate synthase (CS) activities and stress protein HSP72 were measured in soleus (SO), extensor digital longus (EDL) and semitendinuous (ST) muscles. ET induced significant enhancement (<jats:italic>P<\/jats:italic>&lt;0.05) in CS, GR, CAT, TBARs, RCD and HSP72 in SO, EDL and ST. OVR induced higher levels (<jats:italic>P<\/jats:italic>&lt;0.05) of TBARs, RCD and HSP72 compared with ET only in SO, while in EDL and ST all measured parameters ranged at same levels reached during ET. We concluded that stress\u2010induced OVR protocol is fiber type dependent, the SO muscle fiber type I being the most affected by this treatment.<\/jats:p>","DOI":"10.1111\/j.1600-0838.2006.00630.x","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T05:56:07Z","timestamp":1280210167000},"page":"67-76","source":"Crossref","is-referenced-by-count":22,"title":["Overreaching\u2010induced oxidative stress, enhanced HSP72 expression, antioxidant and oxidative enzymes downregulation"],"prefix":"10.1111","volume":"18","author":[{"given":"C. C.","family":"Zoppi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"105","volume-title":"Methods in enzymology","author":"Aebi H.","year":"1984"},{"issue":"24","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"C874","DOI":"10.1152\/ajpcell.1988.255.6.C874","article-title":"MDA content increases in fast and slow twitch skeletal muscle with intensity of exercise in a rat","volume":"255","author":"Alessio HM","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_7_4_1","volume-title":"Theory and methodology of training: the key to athletic performance","author":"Bompa TO.","year":"1998"},{"issue":"2","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/jappl.1996.81.2.731","article-title":"Hydrogen peroxide disrupts Ca2+ release from the sarcoplasmic reticulum of rat skeletal muscle fibres","volume":"81","author":"Brotto MAP","year":"1996","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198806000-00006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.1999.00609.x"},{"issue":"4","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1152\/jappl.1982.53.4.844","article-title":"Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle","volume":"53","author":"Dudley GA","year":"1982","journal-title":"J Appl Physiol"},{"issue":"5","key":"e_1_2_7_9_1","first-page":"409","article-title":"Muscle fatigue and induction of stress protein genes","volume":"22","author":"Essig DA","year":"1997","journal-title":"a dual function of reactive oxygen species?"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-9074-8_17"},{"issue":"3","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/jappl.2000.89.3.1055","article-title":"HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise","volume":"89","author":"Febbraio MA","year":"2000","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_12_1","first-page":"173","volume-title":"Running injuries","author":"Foster C","year":"1997"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373617"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434140-00003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2004344"},{"issue":"4","key":"e_1_2_7_17_1","first-page":"331","article-title":"Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage","volume":"92","author":"Haycock JW","year":"1996","journal-title":"a histochemical, immunocytochemical and electron microscopical study in vitro"},{"issue":"1","key":"e_1_2_7_18_1","first-page":"460","article-title":"Muscle fibre stress in response to exercise","volume":"243","author":"Hernando R","year":"1997","journal-title":"synthesis, accumulation and isoform transitions of 70-kDa heat-shock proteins"},{"issue":"4","key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/jappl.1984.56.4.831","article-title":"Adaptations of skeletal muscle to endurance exercise and their metabolic consequences","volume":"56","author":"Holloszy JO","year":"1984","journal-title":"J Appl Physiol"},{"issue":"1","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1249\/00005768-199501000-00019","article-title":"Markers for monitoring overtraining and recovery","volume":"27","author":"Hooper SL","year":"1995","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"e_1_2_7_21_1","first-page":"670S","article-title":"Exercise and oxidative stress methodology","volume":"72","author":"Jenkins RR.","year":"2000","journal-title":"a critique"},{"key":"e_1_2_7_22_1","first-page":"135","volume-title":"Exercise and sports science reviews","author":"Ji LL.","year":"1995"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-145.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02085.x"},{"key":"e_1_2_7_25_1","first-page":"150","article-title":"Antioxidant enzyme system in rat liver and skeletal muscle","volume":"263","author":"Ji LL","year":"1988","journal-title":"influence of selenium deficiency acute exercise and chronic training"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.31326"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19980004"},{"issue":"5","key":"e_1_2_7_28_1","first-page":"2177","article-title":"Heat shock proteins","volume":"92","author":"Kregel KC.","year":"2002","journal-title":"modifying factors in physiological stress responses and acquired thermotolerance"},{"key":"e_1_2_7_29_1","first-page":"309","volume-title":"Overtraining in sport","author":"Kreider RB.","year":"1998"},{"issue":"7","key":"e_1_2_7_30_1","first-page":"1137","article-title":"Training and overtraining","volume":"30","author":"Kuipers H.","year":"1998","journal-title":"an introduction"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.1.R363"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199807000-00019"},{"issue":"7","key":"e_1_2_7_33_1","first-page":"854","article-title":"Overtraining in endurance athletes","volume":"25","author":"Lehmann M","year":"1993","journal-title":"a brief review"},{"key":"e_1_2_7_34_1","first-page":"7","volume-title":"Overtraining in sport","author":"Lehmann M","year":"1998"},{"issue":"1","key":"e_1_2_7_35_1","first-page":"7","article-title":"Training and overtraining","volume":"37","author":"Lehmann MJ","year":"1997","journal-title":"an overview and experimental results in endurance sports"},{"issue":"1","key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/jappl.1999.86.1.101","article-title":"Human skeletal muscle HSP70 response to training in highly trained rowers","volume":"86","author":"Liu Y","year":"1999","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1989.257.6.E823"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719288"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972617"},{"issue":"3","key":"e_1_2_7_40_1","first-page":"471","article-title":"Effects of physical training on the structure and metabolism of skeletal muscles in athletes","volume":"58","author":"Nemirovskaya TL","year":"1993","journal-title":"Biokhimiya"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)48644-2"},{"key":"e_1_2_7_42_1","first-page":"79","volume-title":"Advances in nutrition and sports","author":"Newsholme EA","year":"1991"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2000.010003123.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1139\/h05-114"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1139\/h03-045"},{"issue":"2","key":"e_1_2_7_46_1","first-page":"83","article-title":"Biochemical aspects of overtraining in endurance sports","volume":"33","author":"Petibois C","year":"2003","journal-title":"the metabolism alteration process syndrome"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(90)90078-T"},{"issue":"2","key":"e_1_2_7_48_1","first-page":"R375","article-title":"Influence of exercise and fiber type on antioxidant enzyme activity in rat skeletal muscle","volume":"266","author":"Powers SK","year":"1994","journal-title":"Am J Physiol"},{"issue":"7","key":"e_1_2_7_49_1","first-page":"987","article-title":"Exercise training\u2010induced alterations in skeletal muscle antioxidant capacity","volume":"31","author":"Powers SK","year":"1999","journal-title":"a brief review"},{"key":"e_1_2_7_50_1","first-page":"69","article-title":"The effect of exercise training on oxidative damage of lipids, proteins and DNA in rat skeletal muscle","volume":"27","author":"Rad\u00e1k Z","year":"1999","journal-title":"evidence for beneficial outcomes"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2042"},{"issue":"1","key":"e_1_2_7_52_1","first-page":"42","article-title":"Supercompensation of muscle glycogen in trained and untrained subjects","volume":"11","author":"Roedde S","year":"1986","journal-title":"Can J Appl Sport Sci"},{"key":"e_1_2_7_53_1","first-page":"269","article-title":"The plasticity of skeletal muscle","volume":"19","author":"Roy RR","year":"1991","journal-title":"effects of neuromuscular activity"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90119-N"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90564-7"},{"issue":"2","key":"e_1_2_7_56_1","first-page":"317","article-title":"Cytokine hypothesis of overtraining","volume":"32","author":"Smith LL.","year":"2000","journal-title":"a physiological adaptation to excessive stress?"},{"issue":"5","key":"e_1_2_7_57_1","first-page":"R1539","article-title":"HSP72 as a complementary protection against oxidative stress induced by exercise in the soleus muscle of rats","volume":"279","author":"Smolka MB","year":"2000","journal-title":"Am J Physiol"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199807000-00020"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(69)13005-0"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240051107"},{"issue":"5","key":"e_1_2_7_61_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1139\/y98-047","article-title":"Radical species in inflammation and overtraining","volume":"76","author":"Tiidus PM.","year":"1998","journal-title":"Can J Physiol Pharmacol"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1269"},{"key":"e_1_2_7_63_1","first-page":"217","article-title":"Differences in effects of various training regimens on metabolism of skeletal muscles","volume":"34","author":"Viru M.","year":"1994","journal-title":"J Sports Med Phys Fitness"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000227320.23847.80"},{"issue":"12","key":"e_1_2_7_65_1","first-page":"1045","article-title":"Exercise\u2010induced oxidative stress","volume":"35","author":"Vollaard NB","year":"2005","journal-title":"myths, realities and physiological relevance"},{"issue":"4","key":"e_1_2_7_66_1","first-page":"1063","article-title":"Mammalian stress response","volume":"72","author":"Welch WJ.","year":"1992","journal-title":"cell physiology, structure\/function of stress proteins, and implications for medicine and disease"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90071-5"},{"key":"e_1_2_7_68_1","doi-asserted-by":"crossref","first-page":"16330","DOI":"10.1016\/S0021-9258(17)46227-2","article-title":"The inactivation of mitochondrial electron transport chain components and ATPase","volume":"265","author":"Zhang Y","year":"1990","journal-title":"J Biol Chem"},{"issue":"2","key":"e_1_2_7_69_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.11606\/issn.2594-5904.rpef.2003.137562","article-title":"Blood oxidative stress, antioxidant enzymes and muscle damage biomarkers changes during a competitive season in soccer players","volume":"17","author":"Zoppi CC","year":"2003","journal-title":"Rev Paul Educ F\u00eds (Portuguese)"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0838.2006.00630.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0838.2006.00630.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T07:44:31Z","timestamp":1697010271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0838.2006.00630.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,12]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1600-0838.2006.00630.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0838.2006.00630.x","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,12]]}}}