{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:12:47Z","timestamp":1790727167623,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC\u2010users (24\u00b12 years; Lindynette<jats:sup>\u00ae<\/jats:sup><jats:italic>n<\/jats:italic>=7, Cilest<jats:sup>\u00ae<\/jats:sup><jats:italic>n<\/jats:italic>=4) and non\u2010OC\u2010users (controls, 24\u00b14 years <jats:italic>n<\/jats:italic>=12) performed one\u2010legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers (<jats:sup>13<\/jats:sup>C\u2010proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3\u2010methyl\u2010histidine (3\u2010MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC\u2010users (two\u2010way analysis of variance, <jats:italic>P<\/jats:italic>&lt;0.05), although the difference seemed to depend on the OC type. Interstitial 3\u2010MH in the skeletal muscle was not different between groups and did not vary by OC type. Exercise did not change myofibrillar protein FSR or 3\u2010MH concentrations. Serum androstenedione and bioavailability of testosterone were lower in OC\u2010users. In conclusion, the results indicate that the use of OC has an inhibiting effect on myofibrillar protein synthesis and the magnitude of the effect may depend on the type of OC. In contrast, there was no effect of OC on myofibrillar protein breakdown in the fed state.<\/jats:p>","DOI":"10.1111\/j.1600-0838.2009.01002.x","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T09:09:17Z","timestamp":1256202557000},"page":"62-72","source":"Crossref","is-referenced-by-count":54,"title":["Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Langberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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