{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:42:55Z","timestamp":1789926175691,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,3,10]],"date-time":"2010-03-10T00:00:00Z","timestamp":1268179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    We reported previously that two otherwise identical training programs at lower (LI) and higher intensity (HI) similarly reduced resting systolic blood pressure (BP) by approximately 4\u20136\u2003mmHg. Here, we determined the effects of both programs on BP\u2010regulating mechanisms, on biomarkers of systemic inflammation and prothrombotic state and on the heart. In this cross\u2010over study (3 \u00d7 10 weeks), healthy participants exercised three times 1\u2003h\/week at, respectively, 33% and 66% of the heart rate (HR) reserve, in a random order, with a sedentary period in between. Measurements, performed at baseline and at the end of each period, involved blood sampling, HR variability, systolic BP variability (SBPV) and cardiac magnetic resonance imaging. Thirty\u2010nine participants (18 men; mean age 59 years) completed the study. Responses were not different between both programs (\n                    <jats:italic>P<\/jats:italic>\n                    &gt;0.05). Pooled data from LI and HI showed a reduction in HR (\u22124.3 \u00b1 8.1%) and an increase in stroke volume (+11 \u00b1 23.1%). No significant effect was seen on SBPV, plasma renin activity, basal nitric oxide and left ventricular mass. Our results suggest that the BP reduction observed appears to be due to a decrease in systemic vascular resistance; training intensity does not significantly affect the results on mechanisms, biomarkers and the heart.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0838.2010.01094.x","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:48:03Z","timestamp":1280191683000},"page":"526-534","source":"Crossref","is-referenced-by-count":13,"title":["Effect of endurance training on blood pressure regulation, biomarkers and the heart in subjects at a higher age"],"prefix":"10.1111","volume":"21","author":[{"given":"V. 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