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Tendon fascicles were dissected from bovine\u2010foot extensors and subjected to cyclic tensile strain (1\u2009<jats:styled-content style=\"fixed-case\">Hz<\/jats:styled-content>) at 30% or 60% of the strain at failure, for 0\u2009h (control), 15\u2009min, 30\u2009min, 1\u2009h, or 5\u2009h. Post loading, a quasi\u2010static test to failure assessed damage. Gene expression at a selected loading regime (1\u2009h at 30% failure strain) was analyzed 6\u2009h post loading by quantitative real\u2010time polymerase chain reaction. Compared with unloaded controls, loading at 30% failure strain took 5\u2009h to lead to a significant decrease in failure stress, whereas loading to 60% led to a significant reduction after 15\u2009min. Loading for 1\u2009h at 30% failure strain did not create significant structural damage, but increased Collagen\u20101\u2010alpha\u2010chain\u20101 and interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL6<\/jats:styled-content>) expression, suggesting a role of <jats:styled-content style=\"fixed-case\">IL6<\/jats:styled-content> in tendon adaptation to exercise. Correlating failure properties with fatigue damage provides a method by which changes in gene expression can be associated with different degrees of fatigue damage.<\/jats:p>","DOI":"10.1111\/j.1600-0838.2011.01410.x","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T10:25:45Z","timestamp":1320315945000},"page":"31-37","source":"Crossref","is-referenced-by-count":78,"title":["Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin\u20106 expression by tenocytes"],"prefix":"10.1111","volume":"23","author":[{"given":"K.","family":"Legerlotz","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of East Anglia  Norwich UK"},{"name":"School of Engineering and Materials Science Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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