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This review aims to provide an overview of studies investigating their effects on skeletal muscle, in particular the repair processes in injured muscle. Muscle injury occurs in diverse situations and the nature of muscle injuries varies significantly, complicating extrapolations between experimental models and \u201creal life.\u201d Classical muscle strain injuries occur at the interphase between the muscle fibers and connective tissue, most often in the myotendinuous junction, whereas contusion or overload injury can damage both myofibers and intramuscular connective tissue. The role of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> in muscle repair is complicated by differences in injury models used, variables evaluated, and time point(s) selected for evaluations.<\/jats:p><jats:p>While the temporal pattern of the influence of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> on muscle repair is difficult to settle on, it appears that a potential beneficial effect of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> in the early phase after injury is not maintained in the long term, or is even negated by a long\u2010term repair deficit. At the cellular level, evidence exists for a negative influence of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> on the muscle stem cell population (satellite cells). At a structural level, it is known that muscle connective tissue undergoes significant remodeling during muscle regeneration, but the potential of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> exposure to alter this response in humans needs investigation.<\/jats:p>","DOI":"10.1111\/j.1600-0838.2012.01463.x","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T16:44:02Z","timestamp":1330620242000},"source":"Crossref","is-referenced-by-count":40,"title":["Rehabilitation of muscle after injury \u2013 the role of anti\u2010inflammatory drugs"],"prefix":"10.1111","volume":"22","author":[{"given":"A. 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