{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:39:44Z","timestamp":1778827184667,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T00:00:00Z","timestamp":1107302400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Skin aging is accompanied by wrinkle formation. At some sites, as the periorbital skin, this is a relatively early phenomenon, variable from one woman to the other and even between the right and left eye.<\/jats:p><jats:p><jats:bold>Purpose: <\/jats:bold> We tested the effect of a preparation with fucose\u2010rich oligo\u2010 and polysaccharide (FROP\u20103) on periorbital wrinkles (crow's feet) on a team of voluntaries.<\/jats:p><jats:p><jats:bold>Method: <\/jats:bold> The efficiency of a preparation containing as active principle a fucose\u2010rich polysaccharide in a base\u2010cream for the treatment of temporal periorbital wrinkles on 20 voluntary women was tested as follows: the women applied the cream twice a day for 4 weeks. Negative replicas were taken on the periorbital skin before and after 4 weeks of application of the cream. The results were evaluated by semi\u2010automated morphometry on the plastic replicas and expressed as the \u2018wrinkle\u2010factor\u2019 obtained by multiplying total wrinkle length in millimeters by the average wrinkle width.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> After 4 weeks of treatment, there was a significant improvement of the periorbital wrinkles for the majority of the voluntary team who tested the cream. On the 29 periocular wrinkles examined 65% showed an improvement at the end of the treatment. In two cases, the improvement was 100% on one eye (disappearance of the crow's feet) and of 75% and 79% on the other eye. On six eyes, there was no significant change after the end of the treatment, and on four eyes a worsening was observed. The age\u2010dependent modifications showed that improvement was independent of age and was the result of individual skin reactions to the cream. The occurrence and the severity of crow's feet is highly individual, and differs from one side of the face to the other for the same person. These strong individual variations explain the highly variable results, not only from one woman to the other but also comparing one side of the face to the other for the same person.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Under the effect of 4 weeks of treatment with the FROP\u20103\u2010containing cream, most of the voluntaries had their periorbital wrinkles attenuated and some women showed a total regression of crow's feet on one of their eyes.<\/jats:p>","DOI":"10.1111\/j.1600-0846.2005.00100.x","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T13:53:17Z","timestamp":1107352397000},"page":"47-52","source":"Crossref","is-referenced-by-count":23,"title":["Effect of a preparation containing a fucose\u2010rich polysaccharide on periorbital wrinkles of human voluntaries"],"prefix":"10.1111","volume":"11","author":[{"given":"C.","family":"Robert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,2]]},"reference":[{"key":"e_1_2_6_2_2","article-title":"Effect of a fucose\u2010rich polysaccharide (FROP\u20103) on skin aging. Indentometric studies on human voluntaries","author":"Robert C","year":"2004","journal-title":"J Cosmetol Dermatol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00031-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(02)00196-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00019-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2003.12.001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2003.06.003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2003.07.002"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0846.2005.00100.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0846.2005.00100.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:43:56Z","timestamp":1697071436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0846.2005.00100.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1111\/j.1600-0846.2005.00100.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0846.2005.00100.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}