{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:22:42Z","timestamp":1773076962485,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Background\/aim: <\/jats:bold> Raynaud's phenomenon (RP) is usually the first symptom in patients with systemic sclerosis (SS) and may precede skin changes by several months or years. Non\u2010invasive measurements of skin elasticity are very sensitive and appropriate for objective and quantitative evaluation of sclerodermatous skin. The aim of this study was to investigate and compare the mechanical properties of the skin in patients with primary, secondary, and suspected secondary RP.<\/jats:p><jats:p><jats:bold>Materials\/methods: <\/jats:bold> A total of 63 patients were studied. They were classified as having scleroderma\u2010type nailfold capillary abnormalities \u2013 17 with indurative phase of scleroderma (group 1), nine with edematous phase of scleroderma (group 2), 18 with suspected secondary RP (group 3) and as having RP\u2010type nailfold capillary abnormalities, 19 with primary RP (group 4). Thirty\u2010nine sex\u2010 and age\u2010matched healthy individuals with normal nailfold capillaroscopy pattern were also studied as controls. Mechanical properties of the skin were evaluated using a non\u2010invasive suction device (Cutometer) equipped with a 2\u2003mm probe. Measurements were performed over five anatomic regions: cheeks, volar forearms, wrists, hands, and proximal phalanx of the fingers. The skin mechanical parameters analyzed were distensibility (Uf), elasticity (Ua\/Uf) and viscoelasticity (Uv\/Ue).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Most demonstrative changes were observed over volar forearms. Patients included in groups 1\u20133 were characterized by significantly lower Uf and higher Uv\/Ue compared with patient group 4 and controls. Patient groups 1 and 2 showed significantly lower Ua\/Uf, as well. There were no significant differences in skin mechanical parameters between patient group 4 and control group.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Mechanical properties of the skin in patients with suspected secondary RP significantly differ from these in patients with primary RP and resemble those in patients with edematous phase of scleroderma. Our findings suggest that the non\u2010invasive measurements of skin elasticity could be helpful in identifying patients with RP at risk of developing SS.<\/jats:p>","DOI":"10.1111\/j.1600-0846.2007.00197.x","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T10:52:42Z","timestamp":1169463162000},"page":"91-94","source":"Crossref","is-referenced-by-count":35,"title":["<i>In vivo<\/i> study of skin mechanical properties in Raynaud's phenomenon"],"prefix":"10.1111","volume":"13","author":[{"given":"Hristo","family":"Dobrev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70072-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90760-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90601-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.154303.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70494-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_5_8_2","volume-title":"Clinical capillaroscopy. A guide to its use in clinical research and practice","author":"Bollinger A","year":"1990"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240907"},{"key":"e_1_2_5_10_2","first-page":"335","volume-title":"Handbook of non\u2010invasive methods and the skin","author":"Barel A","year":"1995"},{"key":"e_1_2_5_11_2","first-page":"1453","article-title":"Report of a meeting of physicians and scientists, Royal Free Hospital School of Medicine, London","volume":"347","author":"Systemic sclerosis: current pathogenic concepts and future prospects for targeted therapy.","year":"1996","journal-title":"Lancet"},{"key":"e_1_2_5_12_2","first-page":"5","article-title":"A study of human skin mechanical properties by means of cutometer","volume":"44","author":"Dobrev H.","year":"2002","journal-title":"Folia Medica (Plovdiv)"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/03091909809032543"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0846.2007.00197.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0846.2007.00197.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:54:50Z","timestamp":1697007290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0846.2007.00197.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,22]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1600-0846.2007.00197.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0846.2007.00197.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,22]]}}}