{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:08:14Z","timestamp":1698685694994},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Objective: <\/jats:bold> Nonmelanoma skin cancer (NMSC) is one of the most common malignancies in men. Objective evaluation by digital dermoscopy, as for pigmented lesions, does not provide sufficient data to discriminate between benign and malignant lesions. Therefore, other techniques have to be developed.<\/jats:p><jats:p><jats:bold>Setting: <\/jats:bold> Hospitalized patients of an academic teaching hospital were evaluated.<\/jats:p><jats:p><jats:bold>Patients and methods: <\/jats:bold> Because the simultaneous measurement of fluorescence and remission of skin is impossible, a principle of subsequent measurement of remission and fluorescence had been developed by our group. This was combined with dermoscopic imaging. VIS\u2010NIR remission spectroscopy was performed using the laboratory device TIDAS. Fluorescence spectroscopy was realized using a SKINSKAN. Fluorescence emission was detected by a highly sensitive PMT\u2010detector. Based on this evaluation, we developed an optimized measuring device (FRIS, fluorescence\u2013remission\u2013imaging sensor) combining sensors for fluorescence, remission and digital imaging with a white light ring illumination, a drilled mirror and fibre optics. FRIS consists of an industrial personal computer with a touch screen combining three UV\u2010VIS spectrometer modules and a white light source for remission measurements and referencing. Furthermore, included are a CCD coloured camera module and an LED white light ring\u2010illumination. Fluorescence emission is realized by a UV\u2010LED with a peak wavelength of 370\u2003nm. System control uses Window<jats:sup>\u00a9<\/jats:sup> frames and a specifically developed software Skinrem3.exe<jats:sup>\u00a9<\/jats:sup>. Using this technology, we performed a pilot study in 19 patients with 30 NMSC\u2010suspicious lesions including: actinic keratosis (<jats:italic>n<\/jats:italic>=10), basal cell carcinoma (BCC; <jats:italic>n<\/jats:italic>=16) and squamous cell carcinoma (SCC; <jats:italic>n<\/jats:italic>=4 with two <jats:italic>in situ<\/jats:italic> carcinomas).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Reproducibility measured or FRIS by relative standard deviation of repeated spectroscopic measurements was &lt;0.1% for remission and 2% for fluorescence. The technology was able to generate typical pattern of remission\u2010corrected fluorescence data. The fluorescence differences at 430\u2003nm allow a differentiation between actinic keratoses and BCC. A decrease of the corrected lesional fluorescence &gt;2\u2003AU indicates BCC. To substantiate the diagnostic potency of this technology, further studies are needed.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> A combination of fluorescence and remission readings of skin provides objective data in NMSC. We developed the FRIS equipment that allows a reproducible measurement and easy handling.<\/jats:p>","DOI":"10.1111\/j.1600-0846.2007.00252.x","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T17:06:52Z","timestamp":1173460012000},"page":"463-471","source":"Crossref","is-referenced-by-count":4,"title":["Fluorescence\u2013remission sensoring of skin tumours: preliminary results"],"prefix":"10.1111","volume":"13","author":[{"given":"Uwe","family":"Wollina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Nelskamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Scheibe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Fa\u00dfler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Dieter","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.2006.13.12"},{"key":"e_1_2_6_3_2","first-page":"50","article-title":"Review of fluorescence diagnosis using porphyrins","volume":"907","author":"Profio AE.","year":"1988","journal-title":"Proc SPIE"},{"key":"e_1_2_6_4_2","first-page":"48","article-title":"In vivo fluorescence in clinical oncology","volume":"3","author":"Andersson\u2010Engels S","year":"1992","journal-title":"fundamental and practical issues"},{"key":"e_1_2_6_5_2","first-page":"1219","article-title":"Fluorescence diagnostics of tumors","volume":"40","author":"Rotomskis R","year":"2004","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_6_6_2","first-page":"531","article-title":"Contact\u2010free spectroscopy of leg ulcers","volume":"116","author":"Schmidt WD","year":"2001","journal-title":"principle, technique, and calculation of spectroscopic wound scores"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-752X.2006.00142.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20248"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00612.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2001)0730178IVFSON2.0.CO2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152572859"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.1925650"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291602"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026428010104"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00118.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01807.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00514769"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05325.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1363"},{"issue":"582","key":"e_1_2_6_20_2","first-page":"99","article-title":"The diagnostic and prognostic value of tumor angiogenesis","author":"Szabo S","year":"1998","journal-title":"Eur J Surg"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08193.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(99)00045-7"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011356"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2001)0730278TAOACM2.0.CO2"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0846.2007.00252.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0846.2007.00252.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T07:24:15Z","timestamp":1697009055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0846.2007.00252.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,9]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1600-0846.2007.00252.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0846.2007.00252.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,9]]}}}