{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:21:40Z","timestamp":1773285700720,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> The quality and extent of leg ulcer healing in deeper skin layers remains poorly defined using standard visual inspection alone. High\u2010resolution ultrasound (HR\u2010US) offers a non\u2010invasive, quantitative and objective assessment of dimensional and structural changes deep within the wound.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> In a prospective, single\u2010center study, healing of chronic, treatment\u2010resistant leg ulcers was monitored by standard photography and HR\u2010US.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Twenty patients with 22 ulcers were enrolled. After study entry, treatment comprised continuation of conventional management (<jats:italic>n<\/jats:italic>=4) or application of Apligraf<jats:sup>\u00ae<\/jats:sup> (<jats:italic>n<\/jats:italic>=17) or Thiersch (<jats:italic>n<\/jats:italic>=1). All ulcers receiving a graft were classified as \u2018clinically healed\u2019 by visual inspection within a maximum of 5 weeks. With conventional management, closure required a period of several months in three out of four cases. After covering the ulcer with Apligraf<jats:sup>\u00ae<\/jats:sup>, the skin reconditioned, resulting in fair skin color and a smooth skin surface in all but one case. HR\u2010US images, however, revealed large subepidermal deficits of elastic and collagenous fibers at the time of \u2018clinical healing\u2019 in 14\/18 engrafted ulcers, findings that are strongly indicative of a weakened skin scaffolding.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> We suggest that the healing process for chronic ulcers can be monitored with both standard visual inspection (photography) and HR\u2010US to allow early intervention.<\/jats:p>","DOI":"10.1111\/j.1600-0846.2008.00342.x","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T23:50:04Z","timestamp":1231890604000},"page":"161-167","source":"Crossref","is-referenced-by-count":8,"title":["Use of high\u2010resolution ultrasound to monitor the healing of leg ulcers: a prospective single\u2010center study"],"prefix":"10.1111","volume":"15","author":[{"given":"Christoph","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorenzo","family":"Angehrn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"11","article-title":"Preventing venous ulcer recurrence","volume":"3","author":"Vowden KR","year":"2006","journal-title":"a review"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_6_4_2","first-page":"605","article-title":"True long\u2010term healing and recurrence of venous leg ulcers following SEPS combined with superficial venous surgery","volume":"34","author":"Nelz\u00e9n O","year":"2007","journal-title":"a prospective study"},{"key":"e_1_2_6_5_2","first-page":"83","article-title":"Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR)","volume":"335","author":"Gohel MS","year":"2007","journal-title":"randomized controlled trial"},{"key":"e_1_2_6_6_2","first-page":"449","article-title":"Venous ulcer","volume":"44","author":"Abbade LP","year":"2005","journal-title":"epidemiology, physiopathology, diagnosis and treatment"},{"key":"e_1_2_6_7_2","volume-title":"Chronic wound care: a clinical source book for healthcare professionals","author":"Kane DP","year":"1997"},{"key":"e_1_2_6_8_2","first-page":"35","article-title":"Understanding chronic wounds","volume":"117","author":"Mustoe TA","year":"2006","journal-title":"a unifying hypothesis on their pathogenesis and implications for therapy"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05222.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.115379"},{"key":"e_1_2_6_11_2","volume-title":"Wound bed preparation: science applied to practice. 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