{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:21:28Z","timestamp":1776896488726,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Forces acting in facial skin have been suggested to show directionality. Non\u2010invasive methods of measuring this directionality may thus provide information related to aging processes. The Reviscometer<jats:sup>\u00ae<\/jats:sup> RVM600 device is capable of measuring directionality of forces on the skin. This device has not been used previously in a published study to evaluate changes in directionality of forces on facial skin with aging.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> The first objective of this pilot study was to investigate relationships between mechanical directionality using the Reviscometer<jats:sup>\u00ae<\/jats:sup> RVM600, the Cutometer<jats:sup>\u00ae<\/jats:sup> MPA580, and aging of the facial skin in a supine position. In addition, the study investigated relationships between mechanical directionality and \u2018skin sagging,\u2019 which may be caused by gravity. To validate this as a new measurement of mechanical directionality, we also performed double\u2010blinded trials on two groups of subjects, with one group using a product containing an anti\u2010aging substance and the other group using a placebo product without an anti\u2010aging substance.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> We examined 91 healthy Japanese women with a mean age of 48.5 years (range, 20\u201379 years) at the three sites on the face using the Reviscometer<jats:sup>\u00ae<\/jats:sup> RVM600 and the Cutometer<jats:sup>\u00ae<\/jats:sup> MPA580, and evaluation was performed for skin sagging in September and November 2008, and January 2009. The Reviscometer<jats:sup>\u00ae<\/jats:sup> RVM600 was used to measure resonance\u2010running time (RRT) every 10\u00b0 from 0\u00b0 to 350\u00b0. Evaluation of skin sagging was undertaken by making marks on the face and using face photographs taken in both sitting and supine positions to calculate the sagging index. Usage testing was conducted on 38 healthy Japanese women in a double\u2010blinded study with one group, using a preparation containing Yomogi AGEs Clearing (YAC) extract and another group using the same preparation without the YAC extract from October 2008 to April 2009. Mean age of these subjects was 44.0 years (range, 30\u201360 years). Measurements were taken at the three sites on the face using the Reviscometer<jats:sup>\u00ae<\/jats:sup> RVM600 and the Cutometer<jats:sup>\u00ae<\/jats:sup> MPA580 and sagging index.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> A significant correlation was identified between RRT parameters and subject age at all three measurement sites. Significant correlations between sagging index and RRT values were found for 110\u2013170\u00b0 and 290\u2013350\u00b0 only at the center of the cheek. Significant differences in RRT values were noted for 110\u2013150\u00b0 and 300\u2013350\u00b0 at this site between subjects with and without the use of YAC extract. A similar trend was found in sagging index for this site alone between subjects with and without YAC extract.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The use of non\u2010invasive procedures to measure skin mechanical parameters on the face in all directions may evaluate aging and effective preventive and restorative support.<\/jats:p>","DOI":"10.1111\/j.1600-0846.2010.00474.x","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T11:27:44Z","timestamp":1294918064000},"page":"101-107","source":"Crossref","is-referenced-by-count":18,"title":["Relevance of the directionality of skin elasticity to aging and sagging of the face"],"prefix":"10.1111","volume":"17","author":[{"given":"Hiroshi","family":"Ohshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Kanamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Akamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb04975.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2008.00302.x"},{"key":"e_1_2_5_4_2","first-page":"341","volume-title":"Handbook of non\u2010invasive methods and the skin","author":"Barbenel JC.","year":"1995"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2006.06.008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108147"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00219-9"},{"key":"e_1_2_5_8_2","first-page":"190","article-title":"Skin Sag of the female face and changes with aging","volume":"21","author":"Murakami M","year":"1997","journal-title":"J Jpn Cosmet Sci Soc (Japanese)"},{"key":"e_1_2_5_9_2","first-page":"10","article-title":"Glycation during human dermal intrinsic and actinic ageing","volume":"145","author":"Jeanmaire C","year":"2001","journal-title":"an in vivo and in vitro model study"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00396.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00364.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00236.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2002.10295.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.09.015"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0846.2010.00474.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0846.2010.00474.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:09:46Z","timestamp":1698710986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0846.2010.00474.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,13]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1111\/j.1600-0846.2010.00474.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0846.2010.00474.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,13]]}}}