{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:26:19Z","timestamp":1791509179314,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Acne is a skin disease which accompanies pathological and morphological changes. Although acne severity is scored by clinicians based on pathological status, aesthetic aspect of acne symptom is also concerned by patients. This study was conducted to examine the usefulness of a 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> image analysis method for the cosmetic efficacy evaluation of an anti\u2010acne cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one healthy volunteers with acne lesions were recruited for the study and treated with an \u2018anti\u2010acne cream\u2019 for 4\u00a0weeks. Acne symptoms on the facial skin were graded by the visual evaluation of photographs taken before and after the treatment. Skin color of acne lesions was and measured by a spectrophotometer. In addition, a 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> image analysis system was used to quantify skin surface roughness and acne volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both visual and spectrophotometric assessments of acne lesions provided similar results indicating that the cream treatment improved acne symptoms significantly. The 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> image analysis of acne lesions confirmed that the cream treatment decreased skin surface roughness and acne volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study demonstrated that the 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> image\u2010based analysis of the skin may be useful for the quantification of acne symptoms of cosmetic relevance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0846.2011.00553.x","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T10:10:26Z","timestamp":1315303826000},"page":"192-198","source":"Crossref","is-referenced-by-count":14,"title":["Cosmetic efficacy evaluation of an anti\u2010acne cream using the 3<scp>D<\/scp> image analysis system"],"prefix":"10.1111","volume":"18","author":[{"given":"Kyung Min","family":"Choi","sequence":"first","affiliation":[{"name":"Dermapro\/Skin Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Dermapro\/Skin Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hwoon","family":"Baek","sequence":"additional","affiliation":[{"name":"Dermapro\/Skin Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Joo","family":"Kang","sequence":"additional","affiliation":[{"name":"Dermapro\/Skin Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chool","family":"Boo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Cell and Matrix Research Institute Kyungpook National University School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sook","family":"Koh","sequence":"additional","affiliation":[{"name":"Dermapro\/Skin Research Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007950100002"},{"key":"e_1_2_5_3_1","first-page":"4","article-title":"Physiopathology of acne vulgaris: recent data, new understanding of the treatments","volume":"14","author":"Henry P","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2001.00487.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120791"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05749.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.51258"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0657"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb04020.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0926-9959.2001.00007.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08083.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34399.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34383.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04874.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.02832.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2005.00096.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3207142"},{"key":"e_1_2_5_18_1","first-page":"385","volume-title":"In vivo examination of the skin: a handbook of non\u2010invasive methods","author":"Westerhof W","year":"1995"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.041"},{"key":"e_1_2_5_20_1","first-page":"646","volume-title":"Proc. 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