{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:14:41Z","timestamp":1698700481944},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There are several available treatments for vitiligo, but measurement of their therapeutic efficacy is not standardized and is somewhat arbitrary based largely on the global impression of the overall response. The purpose of this study was to develop a quantitative method for evaluating the treatment response of vitiligo measuring changes in area using digital image analysis. We applied this parametric model to the evaluation of efficacy of the 308\u00a0nm excimer laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective study, designed as a before and after trial with a single arm. A total of 18 patients were enrolled who had been treated with a 308\u00a0nm excimer laser as monotherapy twice a week for 20 sessions. The repigmentation percentage was calculated by measuring changes in area before and after treatment using digital image analysis and graded on a five\u2010point ordinal scale [global assessment scale (<jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>)]. <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content> was also measured by physician and patient for comparison with our estimates. Additional <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>s were also measured by four different evaluators for inter\u2010rater variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean repigmentation percentage after treatment was 45.3% (range, 0.7\u2013100%). The changes in area after treatment were statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). A substantial agreement of outcomes was observed between physicians and digital image analysis (\u03ba<jats:sub>w<\/jats:sub>\u00a0=\u00a00.78), but lower agreement was observed between patients and digital image analysis (\u03ba<jats:sub>w<\/jats:sub>\u00a0=\u00a00.49). The inter\u2010rater variability for <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content> was substantially low (<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>rippendorff's \u03b1\u00a0=\u00a079.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measurement of changes in area using digital image analysis could be used as a quantitative method in evaluating efficacy of treatment for vitiligo. Because vitiligo lesions can occur in any location with various shapes and sizes, digital image analysis would be a more objective method for measuring treatment response than a <jats:styled-content style=\"fixed-case\">GAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0846.2011.00575.x","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T10:07:10Z","timestamp":1315303630000},"page":"347-355","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative method for measuring therapeutic efficacy of the 308\u00a0nm excimer laser for vitiligo"],"prefix":"10.1111","volume":"18","author":[{"given":"Tae Seok","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Dermatology Guro Hospital Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute for Skin Image Korea University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Wook","family":"Son","sequence":"additional","affiliation":[{"name":"Research Institute for Skin Image Korea University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chil Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Guro Hospital Korea University College of Medicine Seoul Korea"},{"name":"Research Institute for Skin Image Korea University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_2_6_3_1","first-page":"55","article-title":"Topical pimecrolimus in the treatment of vitiligo","volume":"17","author":"Boone B","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2001.tb00012.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90133-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1514"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114752"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00437.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.99069.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00097.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1613"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"e_1_2_6_13_1","first-page":"46","article-title":"Autologous transplantation techniques for vitiligo: how to evaluate treatment outcome","volume":"14","author":"Van Geel NA","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_14_1","first-page":"150","article-title":"A new digital image analysis system useful for surface assessment of vitiligo lesions in transplantation studies","volume":"14","author":"Van Geel N","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","first-page":"30","article-title":"A practical method for the estimation of vitiligo surface area: a comparison between the point counting and digital planimetry techniques","volume":"17","author":"Aydin F","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00558.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70194-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1532"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00509.x"},{"key":"e_1_2_6_21_1","first-page":"13","article-title":"Using a 308\u2010nm excimer laser to treat vitiligo in Asians","volume":"18","author":"Al\u2010Otaibi SR","year":"2009","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/19312450709336664"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08112.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00122.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03562.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2003.00042.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-725X.2005.00124.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2010.00463.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480045006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.010"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.025"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0846.2011.00575.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0846.2011.00575.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T20:39:57Z","timestamp":1698698397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0846.2011.00575.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1600-0846.2011.00575.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0846.2011.00575.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,6]]}}}