{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:59Z","timestamp":1791288719270,"version":"4.3.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>This study aimed to develop a method for the assessment of allergic dermatitis by using the long\u2010wavelength near\u2010infrared spectrum (more than 1000\u00a0nm) to detect intracutaneous allergic type\u2010specific elements. Such a method was realized by establishing a spectral classifier for the spectra of type I and type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> allergic dermatitis reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Near\u2010infrared spectral images of histamine\u2010induced cutaneous reaction (type I) and contact hypersensitivity erythema elicited by squaric acid dibutylester (<jats:styled-content style=\"fixed-case\">SADBE<\/jats:styled-content>; type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) were obtained, and the absorption spectra of normal and inflamed skin were extracted from these spectral images. A spectral classifier was established from these training datasets, and it was then applied to two test cases, red flare by methyl nicotinate (normal) and metal allergy (type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The spectral classifier established by canonical discriminant analysis (<jats:styled-content style=\"fixed-case\">CDA<\/jats:styled-content>) achieved very accurate detection (normal: 87.67%, type I: 87.00%, type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>: 98.5%). Furthermore, the test cases were also correctly classified: the red flare induced by methyl nicotinate was categorized as normal skin and the metal allergy was categorized as a type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> allergic reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest a possible application of near\u2010infrared spectral imaging to the assessment of allergic dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0846.2012.00622.x","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T02:20:14Z","timestamp":1338949214000},"source":"Crossref","is-referenced-by-count":11,"title":["Detection and visualization of intracutaneous allergic type\u2010specific elements using long\u2010wavelength near\u2010infrared hyperspectral imaging"],"prefix":"10.1111","volume":"19","author":[{"given":"Ken","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering Toyohashi University of Technology  Toyohashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Fujiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Division of Dermatology Shimada Municipal Hospital  Shimada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Nakauchi","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering Toyohashi University of Technology  Toyohashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"575","volume-title":"Clinical aspects of immunology","author":"Gell PGH","year":"1963"},{"key":"e_1_2_6_3_1","unstructured":"AngelopoulouE.The reflectance spectrum of human skin. 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