{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:36Z","timestamp":1787015076032,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T00:00:00Z","timestamp":1346371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Reflectance confocal microscopy (\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      )'s interest has been well established for the non\u2010invasive diagnosis of skin cancers, especially melanocytic, and in the differential diagnosis between benign and malignant cutaneous lesions. However, its diagnostic interest in inflammatory skin diseases still needs to be demonstrated. Our purpose was to evaluate the correlation between\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      and conventional histopathology in a series of pustular eruptions of different pathogeny.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Reflectance confocal microscopy analysis was performed in eight consecutive unselected patients in whom the diagnoses of pustular psoriasis, bacterial sur\u2010infection, herpes\u2010type virus skin sur\u2010infection, Sneddon\u2010Wilkinson subcorneal putulosis and Hailey\u2010Hailey disease have been made and images were compared to conventional histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neutrophils within the epidermis exhibited never reported earlier specific features, with either a shiny granular sludge or polylobated particules with a bright granular content. Moreover, some specific etiologies could be identified, such as acantholysis and herpes\u2010type virus\u2010infected keratinocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our studies show a good correlation between\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      and conventional histopathology in pustular eruptions. Reflectance confocal microscopy may play an important role in the differential diagnosis of pustular eruptions; as most of the pathologic clues are epidermal, narrow thickness of the field of imaging, its main technical limitation, is indeed of lesser importance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1600-0846.2012.00662.x","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T06:01:16Z","timestamp":1346392876000},"source":"Crossref","is-referenced-by-count":29,"title":["Reflectance confocal microscopy characteristics of eight cases of pustular eruptions and histopathological correlations"],"prefix":"10.1111","volume":"19","author":[{"given":"S\u00e9bastien","family":"Debarbieux","sequence":"first","affiliation":[{"name":"Dermatology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Depaepe","sequence":"additional","affiliation":[{"name":"Dermatopathology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Poulalhon","sequence":"additional","affiliation":[{"name":"Dermatology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dalle","sequence":"additional","affiliation":[{"name":"Dermatology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Balme","sequence":"additional","affiliation":[{"name":"Dermatopathology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite 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