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The majority of the <jats:italic>HPS<\/jats:italic> genes have been described as novel, but herein we report the identification of a conserved protein family which includes human HPS4, as well as distant homologs for other <jats:italic>HPS<\/jats:italic> genes. Our results suggest that the cellular machinery involved in the HPS syndrome is ancient.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1600-0854.2005.00301.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:12:59Z","timestamp":1117753979000},"page":"534-538","source":"Crossref","is-referenced-by-count":17,"title":["The CHiPS Domain \u2013 Ancient Traces for the Hermansky\u2013Pudlak 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