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A central role has been established for the protease\u2010activated receptor\u20102 of the keratinocyte which effectuates melanin transfer via phagocytosis. What exactly is being phagocytosed \u2013 naked melanin, melanosomes or melanocytic cell parts \u2013 remains to be defined. Analogy of melanocytes to neuronal cells and cells of the haemopoietic lineage suggests exocytosis of melanosomes and subsequent phagocytosis of naked melanin. Otherwise, microscopy studies demonstrate cytophagocytosis of melanocytic dendrites. Other plausible mechanisms are transfer via melanosome\u2010containing vesicles shed by the melanocyte or transfer via fusion of keratinocyte and melanocyte plasma membranes with formation of tunnelling nanotubes. Molecules involved in transfer are being identified. Transfer is influenced by the interactions of lectins and glycoproteins and, probably, by the action of E\u2010cadherin, SNAREs, Rab and Rho GTPases. Further clues as to what mechanism and molecular machinery will arise with the identification of the function of specific genes which are mutated in diseases that affect transfer.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1600-0854.2006.00425.x","type":"journal-article","created":{"date-parts":[[2006,5,18]],"date-time":"2006-05-18T12:50:09Z","timestamp":1147956609000},"page":"769-778","source":"Crossref","is-referenced-by-count":227,"title":["The Quest for the Mechanism of Melanin Transfer"],"prefix":"10.1111","volume":"7","author":[{"given":"Karolien","family":"Van Den 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