{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:17:08Z","timestamp":1792012628457,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T00:00:00Z","timestamp":1158624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>\n                    <jats:bold>Reorganization of actin cytoskeletal dynamics plays a critical role in controlling T\u2010lymphocyte activation and effector functions. Interaction of T\u2010cell receptors (TCR) with appropriate major histocompatability complex\u2013peptide complexes on antigen\u2010presenting cells results in the activation of signaling cascades, leading to the accumulation of F\u2010actin at the cell\u2013cell contact site. This event is required for the formation and stabilization of the immune synapse (IS), a cellular structure essential for the modulation of T\u2010cell responses. Analysis of actin cytoskeletal dynamics following engagement of the TCR has largely focused on the Arp2\/3 regulator, WASp, because of its early identification and its association with human disease. However, recent studies have shown equally important roles for several additional actin regulatory proteins. In this review, we turn the spotlight on the expanding cast of actin regulatory proteins, which co\u2010ordinate actin dynamics at the IS.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0854.2006.00491.x","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T07:01:17Z","timestamp":1158649277000},"page":"1451-1460","source":"Crossref","is-referenced-by-count":66,"title":["Regulation of Cytoskeletal Dynamics at the Immune Synapse: New Stars Join the Actin Troupe"],"prefix":"10.1111","volume":"7","author":[{"given":"Daniel D.","family":"Billadeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis 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