{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:37:05Z","timestamp":1790005025839,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Lysosome\u2010related organelles comprise a group of specialized intracellular compartments that include melanosomes and platelet dense granules (in mammals) and eye pigment granules (in insects). In humans, the biogenesis of these organelles is defective in genetic disorders collectively known as Hermansky\u2013Pudlak syndrome (HPS). Patients with HPS\u20102, and two murine HPS models, carry mutations in genes encoding subunits of adaptor protein (AP)\u20103. Other genes mutated in rodent models include those encoding VPS33A and Rab38. Orthologs of all of these genes in <jats:italic>Drosophila melanogaster<\/jats:italic> belong to the \u2018granule group\u2019 of eye pigmentation genes. Other genes associated with HPS encode subunits of three complexes of unknown function, named biogenesis of lysosome\u2010related organelles complex (BLOC)\u20101, \u20102 and \u20103, for which the <jats:italic>Drosophila<\/jats:italic> counterparts had not been characterized. Here, we report that the gene encoding the <jats:italic>Drosophila<\/jats:italic> ortholog of the HPS5 subunit of BLOC\u20102 is identical to the granule group gene <jats:italic>pink<\/jats:italic> (<jats:italic>p<\/jats:italic>), which was first studied in 1910 but had not been identified at the molecular level. The phenotype of <jats:italic>pink<\/jats:italic> mutants was exacerbated by mutations in AP\u20103 subunits or in the orthologs of VPS33A and Rab38. These results validate <jats:italic>D. melanogaster<\/jats:italic> as a genetic model to study the function of the BLOCs.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1600-0854.2006.00514.x","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T11:46:15Z","timestamp":1165491975000},"page":"154-168","source":"Crossref","is-referenced-by-count":41,"title":["The <i>Drosophila<\/i> Pigmentation Gene <i>pink<\/i> (<i>p<\/i>) Encodes a Homologue of Human Hermansky\u2013Pudlak Syndrome 5 (HPS5)"],"prefix":"10.1111","volume":"8","author":[{"given":"Juan M.","family":"Falc\u00f3n\u2010P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Romero\u2010Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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