{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:44:18Z","timestamp":1776973458473,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Biogenesis of lysosome\u2010related organelles (LROs) complex\u20101 (<jats:styled-content style=\"fixed-case\">BLOC<\/jats:styled-content>\u20101) is an eight\u2010subunit complex involved in lysosomal trafficking. Interacting proteins of these subunits expand the understanding of its biological functions. With the implementation of the na\u00efve Bayesian analysis, we found that a human uncharacterized 20 <jats:styled-content style=\"fixed-case\">kDa<\/jats:styled-content> coiled\u2010coil <jats:styled-content style=\"fixed-case\">KxDL<\/jats:styled-content> protein, <jats:styled-content style=\"fixed-case\">KXD1<\/jats:styled-content>, is a <jats:styled-content style=\"fixed-case\">BLOS1<\/jats:styled-content>\u2010interacting protein. <jats:italic>In vitro<\/jats:italic> binding assays confirmed the interaction between <jats:styled-content style=\"fixed-case\">BLOS1<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">KXD1<\/jats:styled-content>. The mouse <jats:styled-content style=\"fixed-case\">KXD1<\/jats:styled-content> homolog was widely expressed and absent in <jats:italic>Kxd1<\/jats:italic> knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) mice. <jats:styled-content style=\"fixed-case\">BLOS1<\/jats:styled-content> was apparently reduced in <jats:italic>Kxd1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice. Mild defects in the melanosomes of the retinal pigment epithelia and in the platelet dense granules of the <jats:italic>Kxd1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mouse were observed, mimicking a mouse model of mild Hermansky\u2013Pudlak syndrome that affects the biogenesis of LROs.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1600-0854.2012.01375.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T16:09:29Z","timestamp":1336061369000},"page":"1160-1169","source":"Crossref","is-referenced-by-count":38,"title":["The <scp>BLOS1<\/scp>\u2010Interacting Protein <scp>KXD1<\/scp> is Involved in the Biogenesis of Lysosome\u2010Related Organelles"],"prefix":"10.1111","volume":"13","author":[{"given":"Qing","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular and Developmental Biology Institute of Genetics &amp; Developmental Biology Chinese Academy of Sciences  Beijing 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