{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:35:00Z","timestamp":1791250500432,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"vor","delay-in-days":8256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> The effects of estradiol (E<jats:sub>2<\/jats:sub>), progesterone (P), and danazol on the production of interleukin\u20101\u03b2 (IL\u20101\u03b2) and tumor necrosis factor (TNF) by OK\u2010432 (a streptococcal preparation)\u2010stimulated monocytes were examined. E<jats:sub>2<\/jats:sub> and P at physiologic concentrations enhanced IL\u20101\u03b2 and TNF production by monocytes from donors with lower control levels (without steroids added) of IL\u20101\u03b2 and TNF. However, E<jats:sub>2<\/jats:sub> and P at physiologic concentrations did not affect IL\u20101\u03b2 and TNF production by monocytes from donors with higher control levels of IL\u20101\u03b2 and TNF. Danazol inhibited IL\u20101\u03b2 and TNF production by monocytes in a dose\u2010dependent manner from not only donors with lower control levels of IL\u20101\u03b2 and TNF but also donors with higher control levels of IL\u20101\u03b2 and TNF. Danazol at a concentration of 10<jats:sup>\u22126<\/jats:sup> M significantly suppressed IL\u20101\u03b2 and TNF production in the presence of E<jats:sub>2<\/jats:sub> and\/or P at concentrations giving peak responses of IL\u20101\u03b2 production. These findings suggest possible new mechanisms of action for danazol in the treatment of endometriosis and infertility associated with immune abnormalities.<\/jats:p>","DOI":"10.1111\/j.1600-0897.1990.tb01037.x","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T07:57:50Z","timestamp":1368086270000},"page":"45-50","source":"Crossref","is-referenced-by-count":56,"title":["Danazol Suppresses the Production of Interleukin\u20101\u03b2 and Tumor Necrosis Factor by Human 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