{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:21:13Z","timestamp":1771532473685,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":5302,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>PROBLEM: Subclinical intra\u2010amniotic infection is often associated with preterm delivery and may precede it by several weeks. We tested the hypothesis that Interleukin\u20106 (IL\u20106) may be elevated in the midtrimester amniotic fluid of pregnancies destined to deliver preterm.<\/jats:p><jats:p>METHODS: A historical cohort study was designed to compare the amniotic fluid (AF) concentrations of IL\u20106 at 14\u201320 weeks in a group of women subsequently delivering at \u2264 34 weeks (n = 13) with those of women delivering at term (n = 166). Included were singleton gestations with no evidence of fetal structural or chromosomal abnormalities, or maternal conditions known to be associated with preterm delivery (n = 179). Levels of IL\u20106 were measured by immunoassay and correlated with demographic and pregnancy outcome information. Statistical analysis included correlation, one\u2010way ANOVA after log\u2010transformation, contingency tables, logistic regression, and receiver operator characteristic (ROC) curve analysis.<\/jats:p><jats:p>RESULTS: There was an inverse correlation between AF IL\u20106 levels at 15\u201320 weeks and gestational age at delivery (r = \u22120.16, <jats:italic>P<\/jats:italic> = 0.03). Women delivering at \u2264 34 weeks had significantly higher median AF IL\u20106 levels (570 pg\/ml versus 330 pg\/ml, <jats:italic>P &lt;<\/jats:italic> 0.0001), rate of African American race (50% versus 12%, <jats:italic>P<\/jats:italic> = 0.004), and of infants with birth weights &lt; 10th centile (31% versus 7%, <jats:italic>P =<\/jats:italic> 0.02) than women delivering at \u2265 37 weeks. Logistic regression analysis showed that IL\u20106 was independently associated with PTD at \u2264 34 weeks after controlling for race and birth weight centiles (<jats:italic>P<\/jats:italic> = 0.039).<\/jats:p><jats:p>CONCLUSIONS: AF IL\u20106 at 15\u201320 weeks can identify patients at risk for PTD at \u2264 34 weeks, suggesting that a portion of PTD cases have inciting events that take place during the early second trimester.<\/jats:p><jats:p>CAPSULE: Midtrimester amniotic fluid IL\u20106 concentrations are significantly higher in women subsequently delivering preterm at \u226434 weeks compared with those delivering at term.<\/jats:p>","DOI":"10.1111\/j.1600-0897.1997.tb00219.x","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T12:11:15Z","timestamp":1315311075000},"page":"227-231","source":"Crossref","is-referenced-by-count":52,"title":["Elevated Amniotic Fluid Interleukin\u20106 Levels During the Early Second Trimester Are Associated With 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