{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:21:14Z","timestamp":1759332074182},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T00:00:00Z","timestamp":1083888000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>Problem:\u2002<\/jats:bold> The immunological success of pregnancy is thought to depend upon the establishment of a balance between favorable and deleterious cytokines, the current paradigm viewing pregnancy as a T helper (Th)2 cytokine\u2010dependent phenomenon. In this context, a particular attention should be directed to the potential role of interleukin (IL)\u201012, which promotes the development of Th1 responses, in the induction of adverse pregnancy\u2010related phenomena. Indeed, very few data linked the Th1\u2010inducer IL\u201012 to the event of abortion.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this study, we have investigated the maternal and fetal effects of exogenous administration of IL\u201012 to CD1 (BR) ICR mice during the pre\u2010 and peri\u2010implantation period (day 2\u20136 of pregnancy). Animals have been evaluated for parameters of reproductive performance, embryo and fetal developmental toxicity and maternal toxicity.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Intraperitoneal administration of IL\u201012 at concentrations from 2.5 to 10\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg daily did not result in an increase in the murine abortion rate. A statistically significant, although minimal, decrease in the number of somites were found in the embryos of animals treated with IL\u201012 at a dose of 10\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg\/day. However, developmental parameters at birth were similar between the two groups of animals suggesting that alteration of somites might be a transitory state during treatment. An increased body weight gains and reduced feed and water consumption were observed in the mothers treated with the cytokine.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In the present experimental conditions and in this specific strain of mice, IL\u201012 does not exert adverse effects on reproductive performance and induces an only modest harmful action on mothers and embryos.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2004.00167.x","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T14:50:20Z","timestamp":1083941420000},"page":"345-351","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Interleukin\u201012 Administration during the Pre\u2010 and Peri\u2010Implantation Period on Mouse Embryofetal Development"],"prefix":"10.1111","volume":"51","author":[{"given":"Michela","family":"Reina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Broccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Menegola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria Di","family":"Blasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminio","family":"Giavini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,7]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.643"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00264-8"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2002.01104.x"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050400"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01329.x"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(97)00028-4"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01607.x"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00457-4"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00517-3"},{"key":"e_1_2_14_11_2","first-page":"278","article-title":"Interleukin\u201018 as an important new cytokine in pregnancy\u2010 Abstract, VIIth International Congress of Reproductive Immunology, 27\u201330 Oct., New Delhi","volume":"40","author":"Muranaka J","year":"1998","journal-title":"Am J Reprod Immunol"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01091.x"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.12.2944"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7501"},{"key":"e_1_2_14_15_2","first-page":"247","article-title":"Farbemethode zum makroskopischen Nachweis von Implantationsstellen am Uterus der Ratte. 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