{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:24:17Z","timestamp":1777663457069,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T00:00:00Z","timestamp":1083888000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>Problem:\u2002<\/jats:bold> The presence of interleukin\u201018 (IL\u201018) in serum and pre\u2010ovulatory follicular fluid (FF) and its possible correlation to <jats:italic>in\u2010vitro<\/jats:italic> fertilization\/embryo transfer (IVF\/ET) outcome and ovarian hyperstimulation syndrome (OHSS) development.<\/jats:p><jats:p><jats:bold>Method of study:\u2002<\/jats:bold> A prospective study was carried out. Assays for serum and pooled pre\u2010ovulatory FF levels of IL\u201018 were performed on 30 patients who underwent oocyte retrieval for IVF\/ET.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mean serum and FF levels of IL\u201018 were 370.4\u2003\u00b1\u2003224 and 228.9\u2003\u00b1\u2003208\u2003pg\/mL, respectively (<jats:italic>r<\/jats:italic>\u2003=\u20030.77, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Levels of FF IL\u201018 were comparable between the two ovaries (right\u2003=\u2003221\u2003\u00b1\u2003166.8 pg\/mL, left\u2003=\u2003237\u2003\u00b1\u2003171.9\u2003pg\/mL; <jats:italic>r<\/jats:italic>\u2003=\u20030.7550, <jats:italic>P<\/jats:italic>\u2003=\u20030.49). A positive correlation was found between IL\u201018 FF levels and number of retrieved oocytes (<jats:italic>r<\/jats:italic>\u2003=\u20030.45; <jats:italic>P<\/jats:italic>\u2003=\u20030.019). In three patients (10%) who developed OHSS, the mean serum level of IL\u201018 at day of ovum pickup was significantly higher compared with patients without OHSS (620\u2003\u00b1\u2003196\u2003pg\/mL versus 345\u2003\u00b1\u2003251\u2003pg\/mL, respectively, <jats:italic>P<\/jats:italic>\u2003=\u20030.04).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Both pre\u2010ovulatory FF and serum levels of IL\u201018 correlate with the number of retrieved oocytes. The serum IL\u201018 level at day of ovum pickup may predict consequent development of OHSS. Further investigations are warranted to determine the role of IL\u201018 in the folliculogenesis and OHSS pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2004.00172.x","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T14:50:20Z","timestamp":1083941420000},"page":"381-384","source":"Crossref","is-referenced-by-count":19,"title":["Interleukin\u201018 is High in the Serum of IVF Pregnancies with Ovarian Hyperstimulation Syndrome*"],"prefix":"10.1111","volume":"51","author":[{"given":"Guy","family":"Gutman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Soussan\u2010Gutman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Malcov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Lessing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Amit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Azem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,7]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.1.1"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137929"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-11-3-454"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01538-7"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602313"},{"key":"e_1_2_11_7_2","first-page":"483","article-title":"Interleukin\u201018, a proinflammatory cytokine","volume":"113","author":"Dinarello CA","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(00)00015-0"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00093-5"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0563"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.7.1207"},{"key":"e_1_2_11_12_2","first-page":"154","article-title":"Pralnacasan (vertex pharmaceuticals)","volume":"6","author":"Siegmund B","year":"2003","journal-title":"IDrugs"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2001.d01-23.x"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/rp.57.1.195"},{"key":"e_1_2_11_15_2","first-page":"211","article-title":"Systematic review of data concerning etiopathology of ovarian hyperstimulation syndrome","volume":"47","author":"Delvigne A","year":"2002","journal-title":"Int J Fertil Womens Med"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.12.2629"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.12.7060"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045645"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81489-6"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2004.00172.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2004.00172.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2004.00172.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:52:01Z","timestamp":1697233921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2004.00172.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1600-0897.2004.00172.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2004.00172.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}