{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:07:12Z","timestamp":1757704032497},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T00:00:00Z","timestamp":1083888000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>Problem:\u2002<\/jats:bold> We tested the hypothesis that developing ovarian follicles produce factors inhibiting the endotoxin induced inflammatory response.<\/jats:p><jats:p><jats:bold>Method of study:\u2002<\/jats:bold> Pseudopregnant rats were treated with FSH to induced follicular development (FSH\u2010rats). For control we used untreated pseudopregnant rats (PSP\u2010rats) and rats in the follicular phase of the ovarian cycle (C\u2010rats). All rats were infused with either saline or endotoxin. Three days after the infusion rats were sacrificed and kidney specimens were snapfrozen. Cryostat kidney sections were stained for the presence of monocytes, granulocytes, CD11a\u2010 and CD11b\u2010positive cells and for ICAM\u20101 expression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The results show that induction of follicular development in pseudopregnant rats inhibited glomerular infiltration of monocytes and CD11b<jats:sup>+<\/jats:sup> cells, while it did not affect the other parameters, i.e. glomerular granulocyte number, CD11a<jats:sup>+<\/jats:sup> cells and glomerular ICAM\u20101 expression.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Developing ovarian follicles produce factors inhibiting monocyte responses to endotoxin.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2004.00173.x","type":"journal-article","created":{"date-parts":[[2004,5,7]],"date-time":"2004-05-07T14:50:20Z","timestamp":1083941420000},"page":"385-389","source":"Crossref","is-referenced-by-count":3,"title":["Developing Ovarian Follicles Inhibit the Endotoxin\u2010Induced Glomerular Inflammatory Reaction in Pseudopregnant Rats"],"prefix":"10.1111","volume":"51","author":[{"given":"Marijke M.","family":"Faas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerda","family":"Van Der Schaaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Moes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maas Jan","family":"Heineman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,7]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4049\/jimmunol.29.3.255","article-title":"A study on the generalized Shwartzman phenomenon","volume":"29","author":"Apitz K","year":"1935","journal-title":"J Immunol"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90676-3"},{"key":"e_1_2_16_4_2","first-page":"1510","article-title":"Glomerular inflammation in pregnant rats after infusion of low dose endotoxin: an immunohistological study in experimental pre\u2010eclampsia","volume":"147","author":"Faas MM","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.6.1400"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00536.x"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000124153"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(69)90126-7"},{"key":"e_1_2_16_9_2","first-page":"575","article-title":"Ovarian secretion rates of oestrogen, androgens and progesterone in normal women and in women with persistent ovarian follicles","volume":"77","author":"Jong FHd","year":"1974","journal-title":"Acta Endocrinol"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)54162-3"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(03)00037-8"},{"key":"e_1_2_16_12_2","first-page":"365","article-title":"Biology of disease: acute inflammation and microthrombosis induced by endotoxin, interleukin\u20101, and tumor necrosis factor and their implication in gram negative infection","volume":"58","author":"Cybulsky MI","year":"1988","journal-title":"Lab Invest"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01971-9"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(92)90103-K"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(05)80240-7"},{"key":"e_1_2_16_16_2","first-page":"531","article-title":"Sex hormones, immune responses, and autoimmune disease. 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