{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T04:47:56Z","timestamp":1697258876926},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T00:00:00Z","timestamp":1090800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To measure levels of serum P\u2010selectin in patients undergoing controlled ovarian hyperstimulation (COH) cycles and to determine their possible correlation to COH variables.<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> Large university\u2010based infertility and <jats:italic>in vitro<\/jats:italic> fertilization unit.<\/jats:p><jats:p><jats:bold>Patients:\u2002<\/jats:bold> Fourteen consecutive patients undergoing our routine COH protocol for unexplained infertility.<\/jats:p><jats:p><jats:bold>Interventions and Main Outcome Measures:\u2002<\/jats:bold> Blood was drawn three times during the COH cycle: (1) day 2 or 3 of the menstrual cycle, before gonadotropin treatment (Day\u20100); (2) day of or prior to human chorionic gonadotropin (hCG) administration (Day\u2010hCG); and (3) day of ovulation (Day\u2010OVU). Serum levels of sex steroids and P\u2010selectin were compared among the three time points. P\u2010selectin was measured with a commercial quantitative sandwich immunoassay technique. To reduce interpatient variability, the percent difference between the Day\u20100 (non\u2010stimulated, basal) level and the Day\u2010hCG and Day\u2010OVU levels was calculated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> P\u2010selectin level on Day\u2010hCG was significantly higher than on Day\u20100 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and non\u2010significantly higher than on Day\u2010OVU (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.12). No significant correlations were observed between serum P\u2010selectin and patient age, amount of gonadotropins used, or estradiol or progesterone level.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The increase in serum P\u2010selectin level during COH until peak estradiol suggests that COH may potentiate a state of platelet activation which is substantially attenuated after hCG administration.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2004.00194.x","type":"journal-article","created":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T15:16:05Z","timestamp":1090854965000},"page":"139-142","source":"Crossref","is-referenced-by-count":1,"title":["Serum P\u2010selectin Level During Controlled Ovarian Hyperstimulation \u2013 a Preliminary 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