{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:35:20Z","timestamp":1780400120287,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>Problem:\u2002<\/jats:bold>Breeding\u2010induced endometritis (BIE) in the mare is resolved by 36\u2003hr after insemination in resistant mares. However, 10\u201315% susceptible broodmares fail to do so because of impaired uterine contractility between 7 and 19\u2003hr after exposure to seminal or bacterial challenge, which reduces their fertility.<\/jats:p><jats:p><jats:bold>Method of study:\u2002<\/jats:bold>Nitric oxide (NO) in uterine secretions, and expression of nitric oxide synthase (NOS) in uterine biopsies were compared between susceptible and resistant groups 13\u2003hr after insemination.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Susceptible mares had a higher NO in their uterine secretions and greater inducible NOS (iNOS) expression in their biopsies compared with resistant mares.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>The NO mediates smooth muscle relaxation, but its role in persistent BIE has not been determined. Our data suggests a possible role of NO, either directly or in a NO\u2010associated pathway, in delayed uterine clearance.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2005.00270.x","type":"journal-article","created":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T10:35:46Z","timestamp":1112697346000},"page":"230-237","source":"Crossref","is-referenced-by-count":57,"title":["Nitric Oxide Levels and Nitric Oxide Synthase Expression in Uterine Samples from Mares Susceptible and Resistant to Persistent Breeding\u2010induced Endometritis"],"prefix":"10.1111","volume":"53","author":[{"given":"Abdorrahman S.","family":"Alghamdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas N.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy S.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats H. 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