{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:55:06Z","timestamp":1779144906071,"version":"3.51.4"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T00:00:00Z","timestamp":1123200000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>Anti\u2010tumor antibodies have potential as cancer biomarkers. There is relatively limited identification of anti\u2010tumor antibodies in response to ovarian cancer, compared with studies for other cancers. There is also very limited information on the prevalence of anti\u2010tumor antibodies among ovarian cancer patients. Although most anti\u2010tumor antibodies react with antigens common to both tumor and normal tissue, the anti\u2010tumor response tends to be confined to individuals with ovarian cancer, similar to other cancers. Antibodies to HOXA7, a differentiation antigen, have the highest reported prevalence in ovarian cancer (67%). Antibodies to other ubiquitous antigens including NY\u2010ESO\u20101, Ep\u2010CAM (epithelial cell adhesion molecule), HSP\u201090 (heat shock protein 90), and mutated p53 have been identified in ovarian cancer. Anti\u2010tumor antibody specificity reflects the heterogeneity of antigen expression in tumors. Tests based on panels of a combination of anti\u2010tumor antibodies may be more predictive for ovarian cancer, as no single specificity accounts for ovarian tumors. In addition to characterization of anti\u2010tumor antibodies as diagnostic markers, study of anti\u2010tumor antibodies is likely to provide insights into mechanisms of tumor development. There is evidence of antibodies to tumor antigens and of activated T cells, suggesting immune recognition of tumor antigens occurred. Nonetheless, as tumors are not \u2018rejected\u2019, it is likely that there are alterations in the immune system. The basis for tumor growth in the face of immune activity remains to be determined.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2005.00287.x","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T16:16:18Z","timestamp":1123258578000},"page":"55-62","source":"Crossref","is-referenced-by-count":29,"title":["Anti\u2010Tumor Antibodies in Ovarian Cancer"],"prefix":"10.1111","volume":"54","author":[{"given":"Judith L","family":"Luborsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Animesh","family":"Barua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seerin V","family":"Shatavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewabe","family":"Kebede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Abramowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Rotmensch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/172460089801300402"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30643-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13019.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3587-1_3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.14.1054"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200201)2:1<76::AID-PROT76>3.0.CO;2-O"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2532248100"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01514"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.3.4.411"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-004-0560-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0471-y"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206462"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/829450"},{"key":"e_1_2_5_16_2","first-page":"207","article-title":"Serological Analysis of Expression cDNA Libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigens","volume":"103","author":"Chen YT","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_5_17_2","first-page":"1519","article-title":"Tumor\u2010reactive immunoglobulins in ovarian cancer: diagnostic and therapeutic significance? (review)","volume":"5","author":"Taylor DD","year":"1998","journal-title":"Oncol Rep"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0103-37"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/153303460200100406"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.1914"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(03)00070-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2772"},{"key":"e_1_2_5_23_2","first-page":"123","article-title":"Profiling the immune responses in patient sera with peptide and cDNA display libraries","volume":"6","author":"Sioud M","year":"2000","journal-title":"Int J Mol Med"},{"key":"e_1_2_5_24_2","first-page":"4296","article-title":"Natural T cell immunity against cancer","volume":"9","author":"Nagorsen D","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1133324100"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1385\/MB:25:1:19"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18809.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm730"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18805.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(03)90005-4"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-004-0526-8"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041130"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00038.x"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18801.x"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010564"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63306-8"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.07.039"},{"key":"e_1_2_5_38_2","first-page":"1057","article-title":"Comparison of carboxyterminal telopeptide of type I collagen (ICTP) and CA 125 as predictors of prognosis in ovarian cancer","volume":"24","author":"Santala M","year":"2004","journal-title":"Anticancer Res"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20314"},{"key":"e_1_2_5_40_2","first-page":"64","article-title":"Serum markers as prognostic factors in epithelial ovarian cancer: an overview","volume":"21","author":"Maggino T","year":"2000","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90710-O"},{"key":"e_1_2_5_42_2","first-page":"797","article-title":"Autologous antibodies eluted from membrane fragments in human ovarian epithelial neoplastic effusions. II. Tissue specificity and reactivity","volume":"76","author":"Kutteh WH","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/1071-5576(96)00013-5"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90094-8"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1984.tb00134.x"},{"key":"e_1_2_5_46_2","first-page":"1557","article-title":"Humoral immune responses to cathepsin D and glucose\u2010regulated protein 78 in ovarian cancer patients","volume":"3","author":"Chinni SR","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_47_2","first-page":"3468","article-title":"Analysis of the anti\u2010p53 antibody response in cancer patients","volume":"53","author":"Labrecque S","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_5_48_2","first-page":"4782","article-title":"Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer","volume":"9","author":"Kim JH","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208082"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10900"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600439"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011503998"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1349"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991022)84:5<506::AID-IJC10>3.0.CO;2-6"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000915)87:6<824::AID-IJC11>3.0.CO;2-K"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)72431-8"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200304040-00004"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5101"},{"key":"e_1_2_5_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1432::AID-CNCR22>3.0.CO;2-8"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.12.016"},{"key":"e_1_2_5_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050459"},{"key":"e_1_2_5_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(02)85004-7"},{"key":"e_1_2_5_63_2","first-page":"6453","article-title":"Expression of the MAGE\u2010A4 and NY\u2010ESO\u20101 cancer\u2010testis antigens in serous ovarian neoplasms","volume":"9","author":"Yakirevich E","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_64_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18803.x"},{"key":"e_1_2_5_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050484"},{"key":"e_1_2_5_66_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.6102"},{"key":"e_1_2_5_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450504.x"},{"key":"e_1_2_5_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01189.x"},{"key":"e_1_2_5_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(98)00041-8"},{"key":"e_1_2_5_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1093"},{"key":"e_1_2_5_71_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2756"},{"key":"e_1_2_5_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200402000-00015"},{"key":"e_1_2_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.04.024"},{"key":"e_1_2_5_74_2","first-page":"4293","article-title":"Dendritic cell\u2010based vaccines in breast and gynaecologic cancer","volume":"23","author":"Hernando JJ","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_5_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.12.006"},{"key":"e_1_2_5_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20010"},{"key":"e_1_2_5_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000059651.17045.77"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2005.00287.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2005.00287.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2005.00287.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T23:51:24Z","timestamp":1697413884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2005.00287.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1600-0897.2005.00287.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2005.00287.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}