{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:10:45Z","timestamp":1760170245299},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T00:00:00Z","timestamp":1125446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The present study characterizes the immunological responses induced by superantigen and the underlying pathological mechanism using T\u2010cell receptor\u2010transgenic mice (TCR\u2010Tg) to enable the ligand toxic shock syndrome toxin\u20101 (TSST\u20101) to induce a cytokine storm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Three kinds of pregnant mice which could respond to TSST\u20101 at various levels were injected with TSST\u20101 on gestation day 17.5 and then the incidence of fetal\/newborn death, production of cytokines including serum interleukin\u20102 (IL\u20102) and the histological status of the placenta were examined on day 18.5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of fetal\/newborn death and the concentrations of cytokines such as IL\u20102 were higher in TCR\u2010Tg mother than those in other strains of mice. Pathological examinations revealed that the placenta was congestive and apoptotic in TCR\u2010Tg mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Superantigen injection into pregnant mice appears to increase the incidence of fetal\/newborn death through an IL\u20102\u2010dependent immunological pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2005.00305.x","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T08:30:16Z","timestamp":1125477016000},"page":"232-239","source":"Crossref","is-referenced-by-count":1,"title":["Immunological Characterization of Superantigen\u2010induced Intrauterine Fetal and Newborn Death"],"prefix":"10.1111","volume":"54","author":[{"given":"Eriko","family":"Takei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Unno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonoko","family":"Habu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"215","article-title":"Controversies in reproductive immunology","volume":"11","author":"Clark DA","year":"1991","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(00)00060-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(01)00112-7"},{"key":"e_1_2_7_5_2","first-page":"0CR607","article-title":"T\u2010helper (1) cytokines increase during early pregnancy in women with a history of recurrent spontaneous abortion","volume":"8","author":"Rezaei A","year":"2002","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049413"},{"key":"e_1_2_7_7_2","first-page":"93","article-title":"Murine experimental abortion by IL\u20102 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis","volume":"48","author":"Shiraishi H","year":"1996","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_7_8_2","first-page":"115","article-title":"Inhibition of pregnancy viability in mice following IL\u20102 administration","volume":"67","author":"Tezabwala BU","year":"1989","journal-title":"Immunology"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2000.tb02581.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(91)90012-F"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90980-X"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60534-9"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1994.tb01772.x"},{"key":"e_1_2_7_14_2","first-page":"638","article-title":"Study of the biological activities of toxic shock syndrome toxin\u20101: II. 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