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However, with low\u2010dose aspirin (acetylsalicylic acid; ASA) in combination with subcutaneous heparin, the chances of full\u2010term delivery increase. Nevertheless, ASA treatment is avoided in pregnant, ASA\u2010sensitive women with APS.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Rapid oral challenge\u2010desensitization to ASA was performed in four pregnant women with a history of APS and aspirin sensitivity. In three patients, desensitization was performed during pregnancy and before the next pregnancy in the fourth. Desensitization was carried out in the ICU using increasing doses of aspirin (0.1\u2013125\u2003mg) over a 24\u2010hr period.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Successful ASA desensitization was achieved in all the patients. No severe side effects occurred during the desensitization test. Only one patient required a small oral dose of antihistamines.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Aspirin desensitization may be a safe alternative even during pregnancy if carefully monitored and permit patients with APS to receive treatment with ASA. This would constitute a new indication in pregnant women with APS and ASA sensitivity.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2005.00322.x","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:11:13Z","timestamp":1133914273000},"page":"45-50","source":"Crossref","is-referenced-by-count":21,"title":["Aspirin Desensitization in the Treatment of Antiphospholipid Syndrome during Pregnancy in ASA\u2010sensitive Patients"],"prefix":"10.1111","volume":"55","author":[{"given":"Jaume","family":"Alijotas\u2010Reig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar 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