{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:19:49Z","timestamp":1697433589932},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T00:00:00Z","timestamp":1137628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> Immunostimulation reduces murine teratogen\u2010induced birth defects. It is unclear if placental improvement contributes to this outcome. The current study examined murine placental ultrastructure and fetal limb development following maternal methylnitrosourea (MNU) exposure, \u00b1Freund's complete adjuvant (FCA) immunostimulation.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Two murine strains (CD\u20101, C57BL\/6N) were administered MNU on gestation day 9 (GD9), FCA pre\u2010breeding, or FCA\u2003+\u2003MNU. Fetal limb and placental development were examined on GD14.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> MNU decreased placental weight and reduced placental cellular viability; FCA reversed these effects. MNU shortened fetal limbs and increased digital defects in both strains. Placentas were less damaged in C57BL\/6N versus CD\u20101 mice, and distal limb malformations improved only in CD\u20101 mice. FCA immunostimulation also increased pregnancy rate.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Improved fetal outcome from immune\u2010stimulated mice may not be dependent on improved placental morphology. However, placental function and morphology in immune\u2010stimulated mice may not directly correlate, thus functional improvements should be examined for possible relationship to reduced birth defects.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2005.00345.x","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T17:27:54Z","timestamp":1137691674000},"page":"145-155","source":"Crossref","is-referenced-by-count":1,"title":["Prebreeding Maternal Immunostimulation with Freund's Complete Adjuvant Reduces Placental Damage and Distal Limb Defects Caused by Methylnitrosourea"],"prefix":"10.1111","volume":"55","author":[{"given":"Mary","family":"Renee Prater","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt L.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea L.","family":"Laudermilch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Holladay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(97)01011-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0030052"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0158"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6866(1999)19:3<171::AID-TCM1>3.0.CO;2-S"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200012)62:6<420::AID-TERA9>3.0.CO;2-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200012)62:6<413::AID-TERA8>3.0.CO;2-B"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(03)00093-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1191\/0960327102ht292oa"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90047-L"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20176"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20082"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1325"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1990.tb01040.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333418"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2003.08.013"},{"key":"e_1_2_7_17_2","article-title":"Role of maternal dietary antioxidant supplementation in murine placental and fetal limb development","author":"Prater MR","year":"2005","journal-title":"Placenta"},{"key":"e_1_2_7_18_2","first-page":"1213","article-title":"Oxidants, antioxidants and carcinogenesis","volume":"40","author":"Ray G","year":"2002","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.1.154"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/1044667031000137601"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10137"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2005.00345.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2005.00345.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:25:09Z","timestamp":1697415909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2005.00345.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,19]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1600-0897.2005.00345.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2005.00345.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,19]]}}}