{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:50:47Z","timestamp":1790250647049,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>To determine the levels of peripheral blood natural killer (NK) cells in healthy women and recurrent aborters, and the effect of intravenous immunoglobulins (IVIGs) on these levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>A total of 659 women were evaluated for NK cells by means of flow cytofluorimetry: 42 non\u2010pregnant healthy women, 394 non\u2010pregnant recurrent spontaneous abortion (RSA) women, 36 pregnant healthy women and 187 pregnant RSA women. Fifty\u2010four of the pregnant RSA women were treated with IVIG; in 18 of them NK cells were measured immediately before and after the very first IVIG infusion (0.5\u2003g\/kg body weight).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blood NK cell results were increased in RSA pregnant\/non\u2010pregnant women, and significantly reduced by IVIG, even after the very first infusion. In RSA pregnant women treated by means of IVIG therapy, 92.3% success rate was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High levels of NK cells are detected in women affected by RSA. IVIGs are capable of decreasing them with a short\u2010 and long\u2010term efficacy, allowing having a very high success rate of pregnancies in RSA women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1600-0897.2005.00356.x","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T11:32:11Z","timestamp":1138793531000},"page":"232-239","source":"Crossref","is-referenced-by-count":74,"title":["High Levels of Peripheral Blood NK Cells in Women Suffering from Recurrent Spontaneous Abortion are Reverted from High\u2010Dose Intravenous Immunoglobulins"],"prefix":"10.1111","volume":"55","author":[{"given":"Roberto","family":"Perricone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia Di","family":"Muzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Perricone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico De","family":"Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina De","family":"Carolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-F"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199409000-00016"},{"key":"e_1_2_5_4_2","first-page":"65","article-title":"Immunotherapy for unexplained recurrent spontaneous abortion","volume":"8","author":"Daya S","year":"1996","journal-title":"Infertil Reprod Med Clinics N Am"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2003.00080.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.01.011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90235-D"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb00960.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049413"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0021"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.4049\/jimmunol.156.10.4027","article-title":"Endometrial T and NK cells in patients with recurrent spontaneous abortion. 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